Publication: Size reduction efficiency of alpha-mangostin suspension using high-pressure homogenization
Issued Date
2019-01-01
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ISSN
13475223
00092363
00092363
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2-s2.0-85063985128
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Mahidol University
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SCOPUS
Bibliographic Citation
Chemical and Pharmaceutical Bulletin. Vol.67, No.4 (2019), 389-392
Suggested Citation
Waree Limwikrant, Tharahpi Aung, Kotchaphan Chooluck, Satit Puttipipatkhachorn, Keiji Yamamoto Size reduction efficiency of alpha-mangostin suspension using high-pressure homogenization. Chemical and Pharmaceutical Bulletin. Vol.67, No.4 (2019), 389-392. doi:10.1248/cpb.c18-00589 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50588
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Title
Size reduction efficiency of alpha-mangostin suspension using high-pressure homogenization
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Abstract
© 2019 The Pharmaceutical Society of Japan In this study, we aimed to investigate the effects of stabilizers and processing parameters on the size reduction of alpha-mangostin (AMG) using high-pressure homogenization (HPH). The solubility of AMG in various stabilizers was studied. Selected stabilizers were used to prepare AMG suspensions by HPH under different conditions. After HPH, the particle size of AMG suspensions with stabilizers significantly decreased to microns. Percent size reduction efficiency of all AMG suspensions with each stabilizer increased with the increase in the number of homogenization cycles. Sodium lauryl sulfate and poloxamer188 provided a greater extent of particle size reduction than polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer. AMG suspensions with binary stabilizers at higher pressure were also prepared. The use of high pressure increased percent size reduction efficiency.