Publication: The rise and fall of long-latency Plasmodium vivax
Issued Date
2019-04-01
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ISSN
18783503
00359203
00359203
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2-s2.0-85063713412
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.113, No.4 (2019), 163-168
Suggested Citation
N. J. White The rise and fall of long-latency Plasmodium vivax. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.113, No.4 (2019), 163-168. doi:10.1093/trstmh/trz002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51081
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Title
The rise and fall of long-latency Plasmodium vivax
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Abstract
© 2018 The Author(s). Until World War II the only clinical phenotype of Plasmodium vivax generally recognised in medicine was one associated with either a long (8-9 months) incubation period or a similarly long interval between initial illness and the first relapse. Long-latency P. vivax strains' were the first in which relapse, drug resistance and pre-erythrocytic development were described. They were the infections in which primaquine radical cure dosing was developed. A long-latency strain' was the first to be fully sequenced. Although long-latency P. vivax is still present in some parts of Asia, North Africa and the Americas, in recent years it has been largely forgotten.