Publication:
Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting

Issued Date

2019-11-27

Resource Type

Article

ISSN

15376591
10584838

DOI

10.1093/cid/ciz131

Other identifier(s)

2-s2.0-85070458352

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Mahidol University

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SCOPUS

Bibliographic Citation

Clinical Infectious Diseases. Vol.69, No.12 (2019), 2119-2126

Suggested Citation

Mirjam Groger, Luzia Veletzky, Albert Lalremruata, Chiara Cattaneo, Johannes Mischlinger, Rella Manego Zoleko, Johanna Kim, Anna Klicpera, Elias L. Meyer, Daniel Blessborn, Markus Winterberg, Ayola A. Adegnika, Selidji T. Agnandji, Peter G. Kremsner, Benjamin Mordmüller, Ghyslain Mombo-Ngoma, Hans Peter Fuehrer, Michael Ramharter Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting. Clinical Infectious Diseases. Vol.69, No.12 (2019), 2119-2126. doi:10.1093/cid/ciz131 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51300

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Title

Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting

Author(s)

Mirjam Groger
 Luzia Veletzky
 Albert Lalremruata
 Chiara Cattaneo
 Johannes Mischlinger
 Rella Manego Zoleko
 Johanna Kim
 Anna Klicpera
 Elias L. Meyer
 Daniel Blessborn
 Markus Winterberg
 Ayola A. Adegnika
 Selidji T. Agnandji
 Peter G. Kremsner
 Benjamin Mordmüller
 Ghyslain Mombo-Ngoma
 Hans Peter Fuehrer
 Michael Ramharter

Other Contributor(s)

Universität Tübingen
 Mahidol University
 Medizinische Universitat Wien
 Nuffield Department of Clinical Medicine
 Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät
 Veterinarmedizinische Universitat Wien
 German Center for Infection Research (DZIF), Partner Site Tübingen
 German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel
 Centre de Recherches Médicales de Lambaréné

Abstract

© 2019 The Author(s). Background: Plasmodium ovale curtisi and wallikeri are perceived as relapsing malarial parasites. Contrary to Plasmodium vivax, direct evidence for this hypothesis is scarce. The aim of this prospective study was to characterize the reappearance patterns of ovale parasites. Methods: P. ovale spp. infected patients were treated with artemether-lumefantrine and followed biweekly for up to 1 year for the detection of reappearing parasitemia. Molecular analysis of reappearing isolates was performed to identify homologous isolates by genotyping and to define cases of relapse following predefined criteria. Results: At inclusion, 26 participants were positive for P. ovale curtisi and/or P. ovale wallikeri. The median duration of follow-up was 35 weeks. Reappearance of the same P. ovale species was observed in 46% of participants; 61% of P. ovale curtisi and 19% of P. ovale wallikeri infection-free intervals were estimated to end with reappearance by week 32. Based on the predefined criteria, 23% of participants were identified with 1 or 2 relapses, all induced by P. ovale curtisi. Conclusion: These findings are in line with the currently accepted relapse theory inasmuch as the reappearance of P. ovale curtisi strains following initial blood clearance was conclusively demonstrated. Interestingly, no relapse of P. ovale wallikeri was observed.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/123456789/51300

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Scopus 2019