Publication: Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery
Issued Date
2019-10-01
Resource Type
ISSN
15327361
00396060
00396060
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2-s2.0-85071381924
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Mahidol University
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SCOPUS
Bibliographic Citation
Surgery (United States). Vol.166, No.4 (2019), 456-459
Suggested Citation
Alfonso Torquati, Prapimporn Chattranukulchai Shantavasinkul, Philip Omotosho, Leonor Corsino, Anna Spagnoli Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery. Surgery (United States). Vol.166, No.4 (2019), 456-459. doi:10.1016/j.surg.2019.06.037 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51390
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Title
Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery
Abstract
© 2019 Elsevier Inc. Background: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. Methods: In prospective-cohort study, prouroguanylin profile changes were determined during meal stimulation in obese patients 2 weeks before and 2 weeks after Roux-en-Y gastric bypass surgery. We also investigated whether these changes play a role in the anorexigenic effect of Roux-en-Y gastric bypass. Results: The study enrolled 8 healthy lean volunteers and 10 obese patients with type 2 diabetes. Prouroguanylin levels were postprandially decreased at 30 minutes (P =.04) and 60 minutes (P =.008) in obese patients before surgery, and they were increased at 60 minutes (P =.003), 90 minutes (P =.008), and 120 minutes (P =.009) after surgery. We observed a significant difference (P =.001) in fasting prouroguanylin levels before (8.82 ± 1.2 ng/mL) and after (6.05 ± 1.2 ng/mL) Roux-en-Y gastric bypass. Hunger ratings in the fasted state did not change after Roux-en-Y gastric bypass. Instead, subjects demonstrated significantly (P =.01) lower hunger visual analog scale scores than before Roux-en-Y gastric bypass. No correlations between circulating prouroguanylin levels and hunger perception were found before or after Roux-en-Y gastric bypass. Conclusion: Prouroguanylin levels decrease after meal stimulation in obese patients, and they increase after Roux-en-Y gastric bypass, but no correlations exist with hunger visual analog scale scores.