Publication: Clinical characteristics and prognosis of morphea (localized scleroderma) in adults: A retrospective study
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Issued Date
2019-01-01
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ISSN
22288082
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2-s2.0-85070768326
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Mahidol University
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SCOPUS
Bibliographic Citation
Siriraj Medical Journal. Vol.71, No.4 (2019), 297-301
Suggested Citation
Narumol Silpa-archa, Pichanee Chaweekulrat, Natchaya Junsuwan, Chanisada Wongpraparut Clinical characteristics and prognosis of morphea (localized scleroderma) in adults: A retrospective study. Siriraj Medical Journal. Vol.71, No.4 (2019), 297-301. doi:10.33192/Smj.2019.45 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/52091
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Title
Clinical characteristics and prognosis of morphea (localized scleroderma) in adults: A retrospective study
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Abstract
© 2019 Siriraj Medical Journal. Objective: To study the clinical characteristics and prognosis of morphea in Thai adult patients. Methods: The medical records of 81 morphea adult patients who visited Siriraj Hospital, Thailand, between 2006 and 2015, were retrospectively reviewed. The demographics, clinical features, treatments and outcomes were analyzed. Clinical improvement was categorized as excellent (> 80%), partial (1%-80%), and no response. Results: Circumscribed morphea was the most common subtype (34, 42%) of the 81 patients, followed by linear morphea (21, 26%), generalized morphea (14, 17%), en coup de sabre (11, 14%) and Parry-Romberg syndrome (1, 1%). Systemic treatment and ultraviolet A (UVA)1 phototherapy had satisfactory outcomes in 83% and 79% of cases, respectively, providing a partial to excellent response. For overall remission, one year after the treatment, 30% of patients achieved a partial to excellent response. After 2 years, this proportion rose to 50%. The median time to clinical response was 24 months. Conclusion: Morphea is a difficult-to-treat dermatosis, with the majority of the patients having a partial clinical response and a high recurrent rate. Combination of treatment might be a worthy option.