Investigation of antimicrobial and alpha-glucosidase inhibitor activities of Morus alba L.
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Issued Date
2019
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
Faculty of Pharmacy Mahidol University
Suggested Citation
Nichapa Teerakulkanont, Mullika T. Chomnawang, Krit Thirapanmethee, Piyatip Khuntayaporn, มัลลิกา ชมนาวัง, กฤษณ์ ถิรพันธุ์เมธี, ปิยทิพย์ ขันตยาภรณ์ (2019). Investigation of antimicrobial and alpha-glucosidase inhibitor activities of Morus alba L.. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/52392
Title
Investigation of antimicrobial and alpha-glucosidase inhibitor activities of Morus alba L.
Other Contributor(s)
Abstract
Morus alba L. is a medical plant and food that has been used for a long time and
commonly known as mulberry. Mulberry can be cultivated in the sub-tropical area of Asia.
Leaves of mulberry are popularly consumed as mulberry tea. The aim of this study was to
investigate the bioactivities of mulberry leaves in water extract and hydro-ethanol extract.
Antimicrobial activities were evaluated by minimal inhibitory concentration (MIC) and
minimal bactericidal concentration (MBC) assay. Broth microdilution was performed
according to CLSI guidelines. Both mulberry leaves extract, were tested against Bacillus cereus
ATCC 11778, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923,
Staphylococcus epidermidis ATCC 12228, Cutibacterium acnes ATCC 6919 and
Pseudomonas aeruginosa ATCC 9027. All MIC value against tested bacteria were more than
4 mg/ml in all extracts. Besides, both extracts were tested in the alpha-glucosidase inhibition
assay. This study was used acarbose as a standard to compare with mulberry extracts. Alphaglucosidase
was inhibited by acarbose (IC50 = 312.5 μg/ml). The IC50 values of water extract
and 70% ethanol extract were 31.25 μg/ml and 46 μg/ml, respectively. The inhibition of alphaglucosidase
is involved with postprandial hyperglycemia reduction in type 2 diabetes.
Therefore, both mulberry leaves extracts, water extract and 70% ethanol extract, demonstrated
an interesting alpha-glucosidase inhibition activity. Moreover, both extracts were more
effective than acarbose. These might indicate the potential of this plant to develop as a food
supplement in type 2 diabetes patients.
Description
The 1st Pharmaceutical Sciences Asia Conference 2019 Theme : Pharmaceutical Sciences toward Health Innovation in the Disruptive Era. Bangkok Midtown Hotel, Thailand. August 22, 2019, page 59-63