Publication: Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities
6
Issued Date
2020-05-01
Resource Type
ISSN
10902120
00452068
00452068
Other identifier(s)
2-s2.0-85081222736
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Bioorganic Chemistry. Vol.98, (2020)
Suggested Citation
Bhornrawin Akkachairin, Warabhorn Rodphon, Onrapak Reamtong, Mathirut Mungthin, Jumreang Tummatorn, Charnsak Thongsornkleeb, Somsak Ruchirawat Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities. Bioorganic Chemistry. Vol.98, (2020). doi:10.1016/j.bioorg.2020.103732 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/53560
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Title
Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities
Abstract
© 2020 Elsevier Inc. This study reported the discovery of novel compounds containing five-membered ring fused quinoline core structures as anticancer and antimalarial agents. Two libraries containing these core structures, neocryptolepines and carbocycle-fused quinolines, were prepared and evaluated. Compound 3h was found to be much more potent than other analogs against cancer cell lines with high selectivity. Meanwhile, carbocycle-fused quinolines 5h and 5s showed moderate anticancer properties but much less cytotoxicity to normal cell than doxorubicin. In addition, compound 3h also showed much lower cytotoxic against human normal kidney cell line compared to doxorubicin standard. However, only compounds 3s and 3p provided acceptable results for antimalarial activities.