Publication: High Incidence of Antiphospholipid Antibodies in Newly Diagnosed Patients With Lymphoma and a Proposed aPL Predictive Score
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Issued Date
2020-01-01
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ISSN
19382723
10760296
10760296
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2-s2.0-85087630234
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Applied Thrombosis/Hemostasis. Vol.26, (2020)
Suggested Citation
Smith Kungwankiattichai, Yupa Nakkinkun, Weerapat Owattanapanich, Theera Ruchutrakool High Incidence of Antiphospholipid Antibodies in Newly Diagnosed Patients With Lymphoma and a Proposed aPL Predictive Score. Clinical and Applied Thrombosis/Hemostasis. Vol.26, (2020). doi:10.1177/1076029620928392 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/58247
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Title
High Incidence of Antiphospholipid Antibodies in Newly Diagnosed Patients With Lymphoma and a Proposed aPL Predictive Score
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Abstract
© The Author(s) 2020. Given that the presence of antiphospholipid (aPL) antibodies has been proposed to be associated with thrombosis in newly diagnosed patients with lymphoma, we conducted a prospective cohort study on these patients. In all, 154 patients were enrolled. More than half were advanced-stage diffuse large B-cell lymphoma. Approximately one-third (35.7%) of the patients had the presence of aPLs, with single-, double-, and triple-aPL positivities of 29.9%, 5.2%, and 0.6%, respectively. Of the 154 patients, 8 (5.19%) developed symptomatic thrombosis during follow-up. There were no significant differences in the incidences of thrombosis for the aPL-positive and aPL-negative groups (5.5% vs 5.1%; P = 1.000). In a multivariate analysis, patients with male sex and lymphoma stage IV were significant risk factors for aPL positivity, with odds ratio [OR] = 2.22 (95% CI: 1.11-4.45), P =.025, and OR: 2.34 (95% CI: 1.17-4.67), P =.016, respectively. An aPL predictive score of ≥−1 was predictive of aPL positivity, with a sensitivity of 83.6% and specificity of 34.3%.