Publication: Prevalence and clinical manifestations of dengue in older patients in Bangkok Hospital for Tropical Diseases, Thailand
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Issued Date
2020-09-01
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18783503
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2-s2.0-85090026409
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.114, No.9 (2020), 674-681
Suggested Citation
Lay Ngeab Chhong, Kittiyod Poovorawan, Borimas Hanboonkunupakarn, Weerapong Phumratanaprapin, Ngamphol Soonthornworasiri, Chatporn Kittitrakul, Apichart Nontprasert, Sasithon Pukrittayakamee Prevalence and clinical manifestations of dengue in older patients in Bangkok Hospital for Tropical Diseases, Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.114, No.9 (2020), 674-681. doi:10.1093/trstmh/traa043 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/59116
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Title
Prevalence and clinical manifestations of dengue in older patients in Bangkok Hospital for Tropical Diseases, Thailand
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Abstract
© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. BACKGROUND: The global incidence of dengue has increased with the ageing population. We examined the prevalence, clinical manifestations and risk factors associated with dengue severity among older patients. METHODS: A retrospective cohort study was conducted at a hospital in Thailand from 2013 to 2018. Data were collected from patient records. Older patients were those aged ≥60 y, whereas adult patients were aged at least 18 y but younger than 60 y. RESULTS: In total, 1822 patients were included in the study. The prevalence of older dengue was 7.96%. Older dengue patients were at a higher risk of developing dengue haemorrhagic fever (DHF) than adult dengue patients (40.69% vs 30.71%). Haematuria was significantly more frequent in older patients (24.82% vs 3.58%), whereas other clinical manifestations had similar frequencies between the groups. Multivariate logistic regression indicated that hypertension (adjusted OR [aOR]=3.549, 95% CI 1.498 to 8.407) and abdominal pain (aOR=10.904, 95% CI 1.037 to 114.710) were significantly associated with DHF among older patients. CONCLUSIONS: Dengue is common in older adults, who also have a higher incidence of developing DHF. Older patients with dengue and comorbid hypertension and abdominal pain should be monitored for their increasing risk of DHF.