Publication: SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020
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Issued Date
2020-10-01
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ISSN
19326203
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2-s2.0-85094871572
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Mahidol University
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SCOPUS
Bibliographic Citation
PLoS ONE. Vol.15, No.10 October (2020)
Suggested Citation
Chintana Chirathaworn, Manit Sripramote, Piti Chalongviriyalert, Supunnee Jirajariyavej, Phatharaporn Kiatpanabhikul, Jatuporn Saiyarin, Chuleekorn Soudon, Orawan Thienfaidee, Thitisan Palakawong Na Ayuthaya, Chantapat Brukesawan, Dootchai Chaiwanichsiri, Duangnapa Intharasongkroh, Nasamon Wanlapakorn, Jira Chansaenroj, Jiratchaya Puenpa, Ritthideach Yorsaeng, Arunee Thitithanyanont, Rungrueng Kitphati, Anek Mungaomklang, Pijaya Nagavajara, Yong Poovorawan SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020. PLoS ONE. Vol.15, No.10 October (2020). doi:10.1371/journal.pone.0236905 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/59815
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Title
SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020
Author(s)
Chintana Chirathaworn
Manit Sripramote
Piti Chalongviriyalert
Supunnee Jirajariyavej
Phatharaporn Kiatpanabhikul
Jatuporn Saiyarin
Chuleekorn Soudon
Orawan Thienfaidee
Thitisan Palakawong Na Ayuthaya
Chantapat Brukesawan
Dootchai Chaiwanichsiri
Duangnapa Intharasongkroh
Nasamon Wanlapakorn
Jira Chansaenroj
Jiratchaya Puenpa
Ritthideach Yorsaeng
Arunee Thitithanyanont
Rungrueng Kitphati
Anek Mungaomklang
Pijaya Nagavajara
Yong Poovorawan
Manit Sripramote
Piti Chalongviriyalert
Supunnee Jirajariyavej
Phatharaporn Kiatpanabhikul
Jatuporn Saiyarin
Chuleekorn Soudon
Orawan Thienfaidee
Thitisan Palakawong Na Ayuthaya
Chantapat Brukesawan
Dootchai Chaiwanichsiri
Duangnapa Intharasongkroh
Nasamon Wanlapakorn
Jira Chansaenroj
Jiratchaya Puenpa
Ritthideach Yorsaeng
Arunee Thitithanyanont
Rungrueng Kitphati
Anek Mungaomklang
Pijaya Nagavajara
Yong Poovorawan
Abstract
© 2020 Chirathaworn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although Thailand has been fairly effective at controlling the spread of COVID-19, continued disease surveillance and information on antibody response in recovered patients and their close contacts remain necessary in the absence of approved vaccines and antivirals. Here, we examined 217 recovered COVID-19 patients to assess their viral RNA shedding and residual antibodies against SARS-CoV-2. We also evaluated antibodies in blood samples from 308 close contacts of recovered COVID-19 patients. We found that viral RNA remained detectable in 6.6% of recovered COVID-19 cases and up to 105 days. IgM, IgG, and IgA antibodies against SARS-CoV-2 were detected in 13.8%, 88.5%, and 83.4% of the recovered cases 4–12 weeks after disease onset, respectively. Higher levels of antibodies detected were associated with severe illness patients experienced while hospitalized. Fifteen of the 308 contacts (4.9%) of COVID-19 cases tested positive for IgG antibodies, suggesting probable exposure. Viral clearance and the pattern of antibody responses in infected individuals are both crucial for effectively combating SARS-CoV-2. Our study provides additional information on the natural history of this newly emerging disease related to both natural host defenses and antibody duration.