Publication: Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection
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Issued Date
2020-10-30
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ISSN
14203049
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2-s2.0-85095593790
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules (Basel, Switzerland). Vol.25, No.21 (2020)
Suggested Citation
Feng Li, Wipaporn Khanom, Xia Sun, Atchara Paemanee, Sittiruk Roytrakul, Decai Wang, Duncan R. Smith, Guo Chun Zhou Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection. Molecules (Basel, Switzerland). Vol.25, No.21 (2020). doi:10.3390/molecules25215037 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/59864
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Title
Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection
Abstract
Andrographolide is a labdene diterpenoid with potential applications against a number of viruses, including the mosquito-transmitted dengue virus (DENV). In this study, we evaluated the anti-viral activity of three 14-aryloxy analogues (ZAD-1 to ZAD-3) of andrographolide against Zika virus (ZIKV) and DENV. Interestingly, one analogue, ZAD-1, showed better activity against both ZIKV and DENV than the parental andrographolide. A two-dimension (2D) proteomic analysis of human A549 cells treated with ZAD-1 compared to cells treated with andrographolide identified four differentially expressed proteins (heat shock 70 kDa protein 1 (HSPA1A), phosphoglycerate kinase 1 (PGK1), transketolase (TKT) and GTP-binding nuclear protein Ran (Ran)). Western blot analysis confirmed that ZAD-1 treatment downregulated expression of HSPA1A and upregulated expression of PGK1 as compared to andrographolide treatment. These results suggest that 14-aryloxy analogues of andrographolide have the potential for further development as anti-DENV and anti-ZIKV agents.