Rearrangement of the bacterial genome during infection with burkholderia pseudomallei, the cause of melioidosis
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2004
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eng
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Mahidol University
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Maharjan, Bina, Vanaporn Wuthiekanun, วรรณพร วุฒิเอกอนันต์, Wirongrong Chierakul, วิรงค์รอง เจียรกุล, Mongkol Vesaratchavest, มงคล เวสารัชเวศย์, Narisara Chantratita, นริศรา จันทราทิตย์, Wipada Chaowagul, White, Nicholas J, Day, Nicholas PJ, Peacock, Sharon J (2004). Rearrangement of the bacterial genome during infection with burkholderia pseudomallei, the cause of melioidosis. Retrieved from: https://hdl.handle.net/20.500.14594/63415.
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Rearrangement of the bacterial genome during infection with burkholderia pseudomallei, the cause of melioidosis
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Abstract
Recurrent melioidosis occurs in more than 10% of patients in north eastern Thailand, despite an adequate course of antibiotic treatment. Affected patients have a mortality rate equivalecnt ot the first episode, indicating the importance of understanding this process. The aim of this study was to examine the hypothesis that isolates associated with relapse undergo genomic rearrangement as part of a process of survival adaptation and persistence. Seventy patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani with recurrent meliodosis were identified from our database. Isolates from the primary and recurrent episodes were obtained from a -80°C freezer library, and examined in parallel by pulsed field gel electrophoresis. Any pair in which one or more bands were different was considered to represent either a new infecting isolate or genomic rearrangement. Multilocus sequence typing was used in these cases to resolve between the two
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Joint International Tropical Medicine Meeting 2004: Ambassador Hotel, Thailand 29 November-1 December 2004: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2004. p.262.