Exploring the differential evolutionary origins of the two Burkholderia pseudomallei chromosomes
1
Issued Date
2004
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Sarinna Tumapa, สรินนา ทุมาภา, Mongkol Vesaratchavest, มงคล เวสารัชเวศย์, Holden, Matt, White, Nicholas J, Day, Nicholas PJ, Feil, Ed, Peacock, Sharon J (2004). Exploring the differential evolutionary origins of the two Burkholderia pseudomallei chromosomes. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63417
Title
Exploring the differential evolutionary origins of the two Burkholderia pseudomallei chromosomes
Abstract
The complete genome sequence of B.pseudomallei has recently been reported. This is composed of two chromosomes of 4.07 megabases and 3.17 megabases. There is significant functional partitioning between them; the large chromosome encodes more of the core functions associated with cell metabolism, while the small chromosome carries more accessory function genes. The large chromosome also demonstrates a greater level of gene order conservation and a greater number of orthologous genes when compared with other related bacteria, suggesting that the two replicons may have different evolutionary origins. The objective of this study was to explore this further by comparing gene sequence fragments from conserved housekeeping genes contained on the first and second chromosome for 180 B.pseudomallei isolates associated with human disease or obtained from soil.
Description
Joint International Tropical Medicine Meeting 2004: Ambassador Hotel, Thailand 29 November-1 December 2004: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2004. p.261.