Publication: Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules
Accepted Date
2004-06-25
Issued Date
2004-06-25
Copyright Date
2004
Resource Type
Language
eng
ISSN
1476-511X (electronic)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Sibmooh N, Yamanont P, Krudsood S, Leowattana W, Brittenham G, Looareesuwan S, et al. Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules. Lipids Health Dis. 2004 Jun 25;3:15.
Suggested Citation
Nathawut Sibmooh, Paveena Yamanont, Srivicha Krudsood, ศรีวิชา ครุฑสูตร, Wattana Leowattana, วัฒนา เลี้ยววัฒนา, Brittenham, Gary, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Rachanee Udomsangpetch Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules. Sibmooh N, Yamanont P, Krudsood S, Leowattana W, Brittenham G, Looareesuwan S, et al. Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules. Lipids Health Dis. 2004 Jun 25;3:15.. doi:10.1186/1476-511X-3-15 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/732
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Title
Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules
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Abstract
INTRODUCTION: Oxidative stress has been demonstrated in malaria. The potential
oxidative modification of lipoproteins derived from malaria patients was studied.
These oxidized lipids may have role in pathogenesis of malaria.
METHOD: The plasma lipid profile and existence of oxidized forms of very low
density lipoprotein (VLDL), low density lipoprotein (LDL) and high density
lipoprotein (HDL) were investigated in malaria (17 mild and 24 severe patients)
and 37 control subjects. Thiobarbituric acid reactive substances (TBARs),
conjugated dienes, tryptophan fluorescence and fluidity of lipoproteins were
determined as markers of oxidation. The biological effect of malarial
lipoproteins was assessed by the expression of adhesion molecules on endothelial
cells.
RESULTS: Malarial lipoproteins had decreased cholesterol (except in VLDL) and
phospholipid. The triglyceride levels were unchanged. The
cholesterol/phospholipid ratio of LDL was decreased in malaria, but increased in
VLDL and HDL. TBARs and conjugate dienes were increased in malarial lipoproteins,
while the tryptophan fluorescence was decreased. The fluidity of lipoproteins was
increased in malaria. These indicated the presence of oxidized lipoproteins in
malaria by which the degree of oxidation was correlated with severity. Of three
lipoproteins from malarial patients, LDL displayed the most pronounced oxidative
modification. In addition, oxidized LDL from malaria patients increased
endothelial expression of adhesion molecules.
CONCLUSION: In malaria, the lipoproteins are oxidatively modified, and the degree
of oxidation is related with severity. Oxidized LDL from malarial patients
increases the endothelial expression of adhesion molecules. These suggest the
role of oxidized lipoproteins, especially LDL, on the pathogenesis of disease.