Publication: Nitrite in paraffin-stimulated saliva correlates with blood nitrite
8
Issued Date
2021-11-01
Resource Type
ISSN
10898611
10898603
10898603
Other identifier(s)
2-s2.0-85112423796
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nitric Oxide - Biology and Chemistry. Vol.116, (2021), 1-6
Suggested Citation
Supanat Lumbikananda, Thanaporn Sriwantana, Krit Rattanawonsakul, Tipparat Parakaw, Chareerut Phruksaniyom, Kanyawat Rattanasuwan, Pornpun Vivithanaporn, Charoensri Thonabulsombat, Nathawut Sibmooh, Sirada Srihirun Nitrite in paraffin-stimulated saliva correlates with blood nitrite. Nitric Oxide - Biology and Chemistry. Vol.116, (2021), 1-6. doi:10.1016/j.niox.2021.08.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/75990
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Nitrite in paraffin-stimulated saliva correlates with blood nitrite
Abstract
Nitrite anion (NO2−) is a circulating nitric oxide (NO) metabolite considered an endothelial function marker. Nitrite can be produced from nitrate (NO3−) secreted from plasma into saliva. The nitrate reductase of oral bacteria converts salivary nitrate to nitrite, which is swallowed and absorbed into circulation. In this study, we aimed to examine the relevance between these species' salivary and blood levels. We collected three whole saliva samples (unstimulated, paraffin-stimulated, and post-chlorhexidine mouthwash stimulated saliva) and blood from 75 healthy volunteers. We measured the nitrite and nitrate by the chemiluminescence method. The nitrite levels in stimulated saliva and post-mouthwash stimulated saliva exhibited weak correlations with blood nitrite. There was no correlation between nitrite in unstimulated saliva with blood nitrite. The baseline platelet activity, determined as P-selectin expression, negatively correlated with nitrite in plasma and post-mouthwash stimulated saliva. The salivary nitrate in all saliva samples showed correlations with its plasma levels. We conclude that nitrite in stimulated saliva correlates with blood nitrite.