Publication: Types, Clinical Features, and Survival Outcomes of Patients with Acute Myeloid Leukemia in Thailand: A 3-Year Prospective Multicenter Study from the Thai Acute Leukemia Study Group (TALSG)
Issued Date
2021-07-01
Resource Type
ISSN
21522669
21522650
21522650
Other identifier(s)
2-s2.0-85110145095
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Lymphoma, Myeloma and Leukemia. Vol.21, No.7 (2021), e635-e643
Suggested Citation
Chinadol Wanitpongpun, Eakkapol Utchariyaprasit, Weerapat Owattanapanich, Adisak Tantiworawit, Ekarat Rattarittamrong, Pimjai Niparuck, Teeraya Puavilai, Jakrawadee Julamanee, Pirun Saelue, Chantiya Chanswangphuwana, Chantana Polprasert, Chajchawan Nakhakes, Wasithep Limvorapitak, Nonglak Kanitsap, Kannadit Prayongratana, Chantrapa Sriswasdi Types, Clinical Features, and Survival Outcomes of Patients with Acute Myeloid Leukemia in Thailand: A 3-Year Prospective Multicenter Study from the Thai Acute Leukemia Study Group (TALSG). Clinical Lymphoma, Myeloma and Leukemia. Vol.21, No.7 (2021), e635-e643. doi:10.1016/j.clml.2021.03.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76117
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Title
Types, Clinical Features, and Survival Outcomes of Patients with Acute Myeloid Leukemia in Thailand: A 3-Year Prospective Multicenter Study from the Thai Acute Leukemia Study Group (TALSG)
Author(s)
Chinadol Wanitpongpun
Eakkapol Utchariyaprasit
Weerapat Owattanapanich
Adisak Tantiworawit
Ekarat Rattarittamrong
Pimjai Niparuck
Teeraya Puavilai
Jakrawadee Julamanee
Pirun Saelue
Chantiya Chanswangphuwana
Chantana Polprasert
Chajchawan Nakhakes
Wasithep Limvorapitak
Nonglak Kanitsap
Kannadit Prayongratana
Chantrapa Sriswasdi
Eakkapol Utchariyaprasit
Weerapat Owattanapanich
Adisak Tantiworawit
Ekarat Rattarittamrong
Pimjai Niparuck
Teeraya Puavilai
Jakrawadee Julamanee
Pirun Saelue
Chantiya Chanswangphuwana
Chantana Polprasert
Chajchawan Nakhakes
Wasithep Limvorapitak
Nonglak Kanitsap
Kannadit Prayongratana
Chantrapa Sriswasdi
Abstract
Background: Acute myeloid leukemia (AML) is a common, challenging hematologic malignancy worldwide. Thai data on its characteristics and outcomes have never been systematically reported, to our knowledge. The objective of this study was to determine the clinical features and outcomes of Thai patients with AML. Patients and Methods: This was a prospective observational study of nine academic hospitals. Patients with newly diagnosed AML were invited to register online. Results: A total of 679 patients with AML were included. The presence of circulating peripheral blood blasts was correlated with a high white blood cell count. Acute promyelocytic leukemia (APL) had predominantly lower white blood cell counts and higher proportions without peripheral blood blasts compared with non-APL AML. Disseminated intravascular coagulation was commonly presented in APL (37.7%). Splenomegaly and normal platelet count were more frequently seen in patients with Philadelphia chromosome–positive AML. The median follow-up time for those who survived more than 1 year was 28.0 months. One-year overall survival rates for non-APL AML and APL were 31.9% and 88.2%, respectively; 2-year overall survival rates were 29.6% and 88.2%, respectively. Hematopoietic stem cell transplantation could improve survival in non-APL AML. Conclusion: APL should be considered despite absence of peripheral blood blast. This study demonstrates poor outcome of Thai AML and more research to improve outcomes are underway. Expanding access to hematopoietic stem cell transplantation should be considered in Thailand.