Publication:
Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation

2

Issued Date

2021-05-01

Resource Type

Article

ISSN

18767753
18735061

DOI

10.1016/j.scr.2021.102306

Other identifier(s)

2-s2.0-85104951634

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Stem Cell Research. Vol.53, (2021)

Suggested Citation

Warun Maneepitasut, Wasinee Wongkummool, Pirut Tong-ngam, Kornkanok Promthep, Alisa Tubsuwan, Aung Khine Linn, Bunyong Phakdeekitcharoen, Suparerk Borwornpinyo, Narisorn Kitiyanant, Phetcharat Phanthong, Suradej Hongeng Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation. Stem Cell Research. Vol.53, (2021). doi:10.1016/j.scr.2021.102306 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76193

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation

Author(s)

Warun Maneepitasut
 Wasinee Wongkummool
 Pirut Tong-ngam
 Kornkanok Promthep
 Alisa Tubsuwan
 Aung Khine Linn
 Bunyong Phakdeekitcharoen
 Suparerk Borwornpinyo
 Narisorn Kitiyanant
 Phetcharat Phanthong
 Suradej Hongeng

Other Contributor(s)

Ramathibodi Hospital
 Mahidol University
 Institute of Molecular Biosciences, Mahidol University

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is one of the common genetic kidney disorders that are caused by mutations in PKD1 or PKD2 gene. In this report, the MUi026-A human induced pluripotent stem cell (hiPSC) line was established from the skin fibroblasts of a female ADPKD patient who had the PKD1 mutation with c.5878C > T. The iPSC line retained normal karyotype. The cells displayed embryonic stem cell-like characteristics with pluripotency marker expression and were able to differentiate into three germ layers.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/76193

Collections

Scopus 2021