Publication:
Generation of a human induced pluripotent stem cells (MUi015-A) from skin fibroblast of retinoblastoma patient with 13q deletion syndrome

1

Issued Date

2021-04-01

Resource Type

Article

ISSN

18767753
18735061

DOI

10.1016/j.scr.2021.102211

Other identifier(s)

2-s2.0-85100419933

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Stem Cell Research. Vol.52, (2021)

Suggested Citation

Amornrat Tangprasittipap, Sukanya Chumchuen, Gunn Pornratananont, Narisorn Kitiyanant, Suradej Hongeng Generation of a human induced pluripotent stem cells (MUi015-A) from skin fibroblast of retinoblastoma patient with 13q deletion syndrome. Stem Cell Research. Vol.52, (2021). doi:10.1016/j.scr.2021.102211 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76234

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Generation of a human induced pluripotent stem cells (MUi015-A) from skin fibroblast of retinoblastoma patient with 13q deletion syndrome

Author(s)

Amornrat Tangprasittipap
 Sukanya Chumchuen
 Gunn Pornratananont
 Narisorn Kitiyanant
 Suradej Hongeng

Other Contributor(s)

Faculty of Medicine Ramathibodi Hospital, Mahidol University
 Institute of Molecular Biosciences, Mahidol University

Abstract

The 13q deletion syndrome is a rare chromosomal disorder caused by loss of the long arm of chromosome 13, and usually entails developmental delay, intellectual disability, behavioral problems and distinctive facial features. In this study, we successfully generated a human iPSC line (MUi015-A) from skin fibroblasts of a patient who had large deletion of chromosome 13, del(13)(q14q22). The MUi015-A line exhibited embryonic stem cell characteristics with consistent pluripotency marker expression and the capability of differentiating into three germ layers. The cell line provides a good tool in studying pathophysiology of the tumors, drug testing and gene therapy.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/76234

Collections

Scopus 2021