Publication: Factors influencing non-adherence to opioids in cancer patients: a mixed-methods cross-sectional study [version 2; peer review: 2 approved]
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Issued Date
2021-01-01
Resource Type
ISSN
1759796X
20461402
20461402
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2-s2.0-85117263081
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Mahidol University
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SCOPUS
Bibliographic Citation
F1000Research. Vol.9, (2021), 1-20
Suggested Citation
Rattaphol Seangrung, Mallika Ahuja, Koravee Pasutharnchat, Rungwipha Mahawan Factors influencing non-adherence to opioids in cancer patients: a mixed-methods cross-sectional study [version 2; peer review: 2 approved]. F1000Research. Vol.9, (2021), 1-20. doi:10.12688/F1000RESEARCH.27725.1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76330
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Title
Factors influencing non-adherence to opioids in cancer patients: a mixed-methods cross-sectional study [version 2; peer review: 2 approved]
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Abstract
Background: Strong opioids are mainly utilized to attenuate pain in cancer patients. Adherence to analgesic drugs significantly promotes adequate pain management and improves quality of life. We aimed to identify the factors influencing non-adherence to strong opioids in cancer patients. Methods: A descriptive, cross-sectional, two-phased, mixed methodsdesign was conducted prospectively to evaluate a cohort of 101 cancer patients who are currently prescribed strong opioids from a pain clinic in Thailand between January and March 2018. Participants were asked to complete a questionnaire that included the following sections: general characteristics; the Medication Taking Behavior in Thai (MTB-Thai) for assessing adherence to medications; and factorsinfluencing nonadherence, which were analyzed using multivariate logistic regression. In addition, face-to-face in depth interviews were conducted with patients showing non-adherence to strong opioids (MTB-Thai score ≤21) and analyzed using thematic content analysis. Results: Of 101 cancer pain patients that completed the questionnaire, 39.6% showed non-adherence to strong opioids. Illness understanding (P=0.047) and the use of more than three types of pain medication (P=0.032) were significant factors influencing nonadherence.Qualitative analysis indicated that fear of long-term outcomes, opioid side effects, ineffective pain control, attempts to make the regimen more acceptable, poor understanding, and nonacceptance of disease related to non-adherence. Conclusion: Non-adherence to opioids for cancer patients is a common problem. Awareness of patient factors, medication-related factors, and illness-related factors will provide the knowledge and adequate advice that may enhance adherence to medications.