Publication: Role of laminin and cognate receptors in cholangiocarcinoma cell migration
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Issued Date
2021-01-01
Resource Type
ISSN
19336926
19336918
19336918
Other identifier(s)
2-s2.0-85106244494
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cell Adhesion and Migration. Vol.15, No.1 (2021), 152-165
Suggested Citation
Kittiya Islam, Parichut Thummarati, Pakkanun Kaewkong, Banchob Sripa, Tuangporn Suthiphongchai Role of laminin and cognate receptors in cholangiocarcinoma cell migration. Cell Adhesion and Migration. Vol.15, No.1 (2021), 152-165. doi:10.1080/19336918.2021.1924422 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76376
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Title
Role of laminin and cognate receptors in cholangiocarcinoma cell migration
Abstract
Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated with lymphatic invasion and the presence of ITGB4 was also associated with short survival time. ITGB4 silencing revealed it as the receptor for laminin-induced HuCCA-1 migration, but KKU-213 utilized 37/67-kDa laminin receptor (LAMR) instead. These findings highlight the role of ITGB4 and LAMR in transducing laminin induction of CCA cell migration and the potential of ITGB4 as diagnostic and prognostic biomarkers for CCA.