Publication:
Copper-Catalyzed Decarboxylative Cycloaddition of Alkynyl Carboxylic Acids and Sodium Azide with Epoxides and Ethers

1

Issued Date

2021-09-27

Resource Type

Article

ISSN

23656549

DOI

10.1002/slct.202102494

Other identifier(s)

2-s2.0-85115683260

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

ChemistrySelect. Vol.6, No.36 (2021), 9632-9636

Suggested Citation

Danupat Beukeaw, Sirilata Yotphan Copper-Catalyzed Decarboxylative Cycloaddition of Alkynyl Carboxylic Acids and Sodium Azide with Epoxides and Ethers. ChemistrySelect. Vol.6, No.36 (2021), 9632-9636. doi:10.1002/slct.202102494 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76588

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Title

Copper-Catalyzed Decarboxylative Cycloaddition of Alkynyl Carboxylic Acids and Sodium Azide with Epoxides and Ethers

Author(s)

Danupat Beukeaw
 Sirilata Yotphan

Other Contributor(s)

Mahidol University

Abstract

Copper-catalyzed decarboxylative cycloaddition of alkynyl carboxylic acids and sodium azide with structurally different epoxides and ethers has been reported for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles. These one-pot transformations are likely to proceed through a mechanism that involves an in situ generated organic azide intermediate, a decarboxylative formation of copper-alkyne component, and a ring closure to form triazole product. The present three-component protocols offer several advantages including using economic, bench stable and safe azide source, simple and convenient experimental procedures, high product yields, excellent regioselectivity, wide substrate scope and good functional group tolerance, which could promote their potential synthetic applications in many related areas.

Keyword(s)

Chemistry

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URI

https://repository.li.mahidol.ac.th/handle/123456789/76588

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Scopus 2021