Publication: Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region
2
Issued Date
2021-10-01
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ISSN
26666065
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2-s2.0-85112352039
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Mahidol University
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SCOPUS
Bibliographic Citation
The Lancet Regional Health - Western Pacific. Vol.15, (2021)
Suggested Citation
Xing Sun, Ru Li, Yueming Cai, Adeeba Al-Herz, Manjari Lahiri, Minhaj Rahim Choudhury, Rudy Hidayat, Bagus Putu Putra Suryana, Yuko Kaneko, Keishi Fujio, Nguyen Van Hung, Sapan Pandya, Leong Khai Pang, Wanruchada Katchamart, Keshav Raj Sigdel, Buddhi Paudyal, Pongthorn Narongroeknawin, Parawee Chevaisrakul, Feng Sun, Yu Lu, Carmen Ho, Swan Sim Yeap, Zhanguo Li Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region. The Lancet Regional Health - Western Pacific. Vol.15, (2021). doi:10.1016/j.lanwpc.2021.100240 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/77823
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Title
Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region
Author(s)
Xing Sun
Ru Li
Yueming Cai
Adeeba Al-Herz
Manjari Lahiri
Minhaj Rahim Choudhury
Rudy Hidayat
Bagus Putu Putra Suryana
Yuko Kaneko
Keishi Fujio
Nguyen Van Hung
Sapan Pandya
Leong Khai Pang
Wanruchada Katchamart
Keshav Raj Sigdel
Buddhi Paudyal
Pongthorn Narongroeknawin
Parawee Chevaisrakul
Feng Sun
Yu Lu
Carmen Ho
Swan Sim Yeap
Zhanguo Li
Ru Li
Yueming Cai
Adeeba Al-Herz
Manjari Lahiri
Minhaj Rahim Choudhury
Rudy Hidayat
Bagus Putu Putra Suryana
Yuko Kaneko
Keishi Fujio
Nguyen Van Hung
Sapan Pandya
Leong Khai Pang
Wanruchada Katchamart
Keshav Raj Sigdel
Buddhi Paudyal
Pongthorn Narongroeknawin
Parawee Chevaisrakul
Feng Sun
Yu Lu
Carmen Ho
Swan Sim Yeap
Zhanguo Li
Other Contributor(s)
Siriraj Hospital
Graduate School of Medicine
Peking University People's Hospital
Peking University Shenzhen Hospital
V.S. Hospital
Subang Jaya Medical Centre
Bach Mai Hospital
Brawijaya University
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Al-Amiri Hospital
NUS Yong Loo Lin School of Medicine
Keio University School of Medicine
Nankai University
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Bangabandhu Sheikh Mujib Medical University
Phramongkutklao College of Medicine
The University of Hong Kong
Peking University Health Science Center
Tan Tock Seng Hospital
Patan Academy of Health Sciences
Graduate School of Medicine
Peking University People's Hospital
Peking University Shenzhen Hospital
V.S. Hospital
Subang Jaya Medical Centre
Bach Mai Hospital
Brawijaya University
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Al-Amiri Hospital
NUS Yong Loo Lin School of Medicine
Keio University School of Medicine
Nankai University
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Bangabandhu Sheikh Mujib Medical University
Phramongkutklao College of Medicine
The University of Hong Kong
Peking University Health Science Center
Tan Tock Seng Hospital
Patan Academy of Health Sciences
Abstract
Background: Clinical remission is an attainable goal for Rheumatoid Arthritis (RA). However, data on RA remission rates from multinational studies in the Asia-Pacific region are limited. We conducted a cross-sectional multicentric study to evaluate the clinical remission status and the related factors in RA patients in the Asia-Pacific region. Methods: RA patients receiving standard care were enrolled consecutively from 17 sites in 11 countries from APLAR RA SIG group. Data were collected on-site by rheumatologists with a standardized case-report form. Remission was analyzed by different definitions including disease activity score using 28 joints (DAS28) based on ESR and CRP, clinical disease activity index (CDAI), simplified disease activity index (SDAI), Boolean remission definition, and clinical deep remission (CliDR). Logistic regression was used to determine related factors of remission. Findings: A total of 2010 RA patients was included in the study, the overall remission rates were 62•3% (DAS28-CRP), 35•5% (DAS28-ESR), 30•8% (CDAI), 26•5% (SDAI), 24•7% (Boolean), and 17•1% (CliDR), respectively, and varied from countries to countries in the Asia-Pacific region. Biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) prescription rate was low (17•9%). Compared to patients in non-remission, patients in remission had higher rates of b/tsDMARDs usage and lower rates of GC usage. The favorable related factors were male sex, younger age, fewer comorbidities, fewer extra-articular manifestations (EAM), and use of b/tsDMARDs, while treatment with GC was negatively related to remission. Interpretation: Remission rates were low and varied in the Asia-Pacific region. Treatment with b/tsDMARDs and less GC usage were related to higher remission rate. There is an unmet need for RA remission in the Asia-Pacific region.