Publication: Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)
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Issued Date
2021-05-01
Resource Type
ISSN
16000536
01051873
01051873
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2-s2.0-85096974814
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Mahidol University
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SCOPUS
Bibliographic Citation
Contact Dermatitis. Vol.84, No.5 (2021), 326-331
Suggested Citation
Thanisorn Sukakul, Jakob Dahlin, Ann Pontén, Annarita Antelmi, Magnus Bruze, Nils Hamnerius, Inese Hauksson, Marléne Isaksson, Tina Lejding, Cecilia Svedman Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide). Contact Dermatitis. Vol.84, No.5 (2021), 326-331. doi:10.1111/cod.13728 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78271
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Title
Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)
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Abstract
Background: Polyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad-spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed, we have included PHMB as a screening allergen since 2016. Objective: To report the prevalence of positive patch test reactions to PHMB as a screening allergen in patients with suspected allergic contact dermatitis. Methods: A retrospective analysis of 1760 patch tested patients from July 2016 to December 2018 was performed. Polyaminopropyl biguanide 2.0% aqua was included in the extended Malmö baseline series during the study period. Results: Of all patients, 1204 (68.4%) were female. Positive patch test reactions were reported in 19 patients (1.1%). The most common sites of lesions were face, head, and neck (52.6%). There was a significant correlation between concomitant reactions to PHMB and other cosmetic-related allergens. Conclusion: The prevalence of positive reactions to PHMB was higher than that previously reported. Patch testing with PHMB should be performed in patients with dermatitis who have lesions on the face, head, and neck.