Publication: Cutaneous macroglobulinosis presenting as serpiginous purpura, a case report and literature review
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2021-01-01
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11787015
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2-s2.0-85113990576
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Mahidol University
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Clinical, Cosmetic and Investigational Dermatology. Vol.14, (2021), 1057-1064
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Siriorn Sukanjanapong, Kumutnart Chanprapaph, Suthinee Rutnin, Paisan Boonsakan, Sulada Pukiat (2021). Cutaneous macroglobulinosis presenting as serpiginous purpura, a case report and literature review. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78629.
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Cutaneous macroglobulinosis presenting as serpiginous purpura, a case report and literature review
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Abstract
Cutaneous macroglobulinosis is a rare manifestation of Waldenstrom macroglo-bulinemia when there is deposition of IgM in the dermis. The clinical presentation varies from skin colored to pink papules and ulcerative nodules on trunk, extensor surfaces of upper and lower limbs to hyperkeratotic lesions on the soles. We herein report a 78-year-old-male with Waldenstrom macroglobulinemia who presented with serpiginous purpura. The differ-ential diagnoses included occlusion of vessel lumen by the lymphoplasmacytoid cells, high level of IgM or cryoglobulin, as well as small to medium vasculitis secondary to Waldenstrom macroglobulinemia. The histopathology revealed vasculopathy and vasculitis, while further immunohistochemistry highlighted deposition in the vessel lumen and vessel wall with IgM, suggesting the diagnosis of cutaneous macroglobulinosis. In this case report, we discuss this rare presentation and reviewed previous cases of cutaneous macroglobulinosis.