Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis
1
Issued Date
2023-01-01
Resource Type
eISSN
24146366
Scopus ID
2-s2.0-85146746915
Journal Title
Tropical Medicine and Infectious Disease
Volume
8
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tropical Medicine and Infectious Disease Vol.8 No.1 (2023)
Suggested Citation
Sornsenee P., Wilairatana P., Kotepui K.U., Masangkay F.R., Romyasamit C., Kotepui M. Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis. Tropical Medicine and Infectious Disease Vol.8 No.1 (2023). doi:10.3390/tropicalmed8010035 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81977
Title
Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis
Other Contributor(s)
Abstract
The roles of anti-inflammatory cytokines in the pathogenesis of severe malaria have been widely studied, and the role of IL-10 in the pathogenesis of severe malaria remains unclear. Therefore, we performed a systematic review and meta-analysis to determine the difference in IL-10 levels between patients with severe malaria and those with non-severe malaria. The search for relevant studies was performed using PubMed, Scopus, and Embase from 1 February 2022 to 12 February 2022. The quality of the included studies was assessed according to the guidelines of the Strengthening the Reporting of Observational Studies in Epidemiology. The random-effects model was used to estimate the pooled effect. In all, 1215 studies were identified, and 19 were included in the quantitative syntheses. The results showed that patients with severe malaria had a higher IL-10 level than those with non-severe malaria (p = 0.03, pooled standardized mean difference: 0.74, 95% CI: 0.08–1.40, I2: 97.22%, 19 studies/21 sub studies). The meta-analysis results demonstrated increased IL-10 levels in patients with severe malaria compared with those with non-severe malaria. However, with the heterogeneity of the meta-analysis results, further studies are required to confirm the changes in the IL-10 levels according to the severity of malaria and to investigate whether a combination of other severity parameters with IL-10 levels could be an alternative marker for severe malaria.