Blood Donors with Thalassemic Trait, Glucose-6-Phosphate Dehydrogenase Deficiency Trait, and Sickle Cell Trait and Their Blood Products: Current Status and Future Perspective
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Issued Date
2023-01-05
Resource Type
eISSN
19437730
Scopus ID
2-s2.0-85144108664
Pubmed ID
35943550
Journal Title
Laboratory medicine
Volume
54
Issue
1
Start Page
6
End Page
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Laboratory medicine Vol.54 No.1 (2023) , 6-12
Suggested Citation
Noulsri E., Lerdwana S. Blood Donors with Thalassemic Trait, Glucose-6-Phosphate Dehydrogenase Deficiency Trait, and Sickle Cell Trait and Their Blood Products: Current Status and Future Perspective. Laboratory medicine Vol.54 No.1 (2023) , 6-12. 12. doi:10.1093/labmed/lmac061 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82468
Title
Blood Donors with Thalassemic Trait, Glucose-6-Phosphate Dehydrogenase Deficiency Trait, and Sickle Cell Trait and Their Blood Products: Current Status and Future Perspective
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
The use of blood products for different medical purposes has increased in recent years. To meet increasing demand, some blood centers allow volunteer donors with thalassemic trait, glucose-6-phosphate dehydrogenase deficiency (G6PD) trait, and sickle cell trait (SCT) to donate blood if their hemoglobin values fall within acceptable ranges and show no signs of hemolysis. Currently, there are no standard guidelines or policies regarding the use or management of blood products obtained from these donors. However, in recent years, there has been advanced research on eligible donors who have these underlying conditions. In this review, we summarize the current knowledge from in vitro and in vivo studies regarding donor characteristics, changes in physical and biochemical parameters in blood products during processing and storage, and posttransfusion efficacy of blood products. In addition, we discuss some unresolved issues concerning blood products from thalassemic trait, G6PD-deficiency trait, and SCT donors.