Axonal and myelin changes and their inter-relationship in the optic radiations in people with multiple sclerosis
Issued Date
2023-01-01
Resource Type
eISSN
20552173
Scopus ID
2-s2.0-85148652610
Journal Title
Multiple Sclerosis Journal - Experimental, Translational and Clinical
Volume
9
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Multiple Sclerosis Journal - Experimental, Translational and Clinical Vol.9 No.1 (2023)
Suggested Citation
Krijnen E.A. Axonal and myelin changes and their inter-relationship in the optic radiations in people with multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical Vol.9 No.1 (2023). doi:10.1177/20552173221147620 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82574
Title
Axonal and myelin changes and their inter-relationship in the optic radiations in people with multiple sclerosis
Author(s)
Other Contributor(s)
Abstract
Background: The imaging g-ratio, estimated from axonal volume fraction (AVF) and myelin volume fraction (MVF), is a novel biomarker of microstructural tissue integrity in multiple sclerosis (MS). Objective: To assess axonal and myelin changes and their inter-relationship as measured by g-ratio in the optic radiations (OR) in people with MS (pwMS) with and without previous optic neuritis (ON) compared to healthy controls (HC). Methods: Thirty pwMS and 17 HCs were scanned on a 3Tesla Connectom scanner. AVF and MVF, derived from a multi-shell diffusion protocol and macromolecular tissue volume, respectively, were measured in normal-appearing white matter (NAWM) and lesions within the OR and used to calculate imaging g-ratio. Results: OR AVF and MVF were decreased in pwMS compared to HC, and in OR lesions compared to NAWM, whereas the g-ratio was not different. Compared to pwMS with previous ON, AVF and g-ratio tended to be higher in pwMS without prior ON. AVF and MVF, particularly in NAWM, were positively correlated with retinal thickness, which was more pronounced in pwMS with prior ON. Conclusion: Axonal measures reflect microstructural tissue damage in the OR, particularly in the setting of remote ON, and correlate with established metrics of visual health in MS.