Lymphomatosis cerebri with coexistent anti-N-methyl-D-aspartate receptor antibody: A case report
1
Issued Date
2023-01-01
Resource Type
ISSN
09196544
eISSN
14401789
Scopus ID
2-s2.0-85148656144
Pubmed ID
36811198
Journal Title
Neuropathology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neuropathology (2023)
Suggested Citation
Rattanathamsakul N., Ongphichetmetha T., Weerachotisakul P., Tisavipat N., Cheunsuchon P., Jitprapaikulsan J. Lymphomatosis cerebri with coexistent anti-N-methyl-D-aspartate receptor antibody: A case report. Neuropathology (2023). doi:10.1111/neup.12899 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82722
Title
Lymphomatosis cerebri with coexistent anti-N-methyl-D-aspartate receptor antibody: A case report
Author's Affiliation
Other Contributor(s)
Abstract
Diagnosis of lymphomatosis cerebri (LC) is usually delayed because of its rarity and the need for pathological confirmation. The association of LC with humoral immunity has scarcely been reported. Herein, we present a woman with a 2-week history of dizziness and gait ataxia, followed by diplopia, altered mental status, and spasticity of all limbs. Magnetic resonance imaging (MRI) of the brain showed multifocal lesions involving bilateral subcortical white matter, deep gray structures, and brainstem. Oligoclonal bands and anti-N-methyl-D-aspartate receptor (NMDAR) antibodies were present in cerebrospinal fluid (CSF) twice. She was initially treated with methylprednisolone but still worsening. A stereotactic brain biopsy confirmed the diagnosis of LC. This is a report on the distinctive coexistence of the rare CNS lymphoma variant and the anti-NMDAR antibody.