Resveratrol oligomers from roots of Ampelocissus martini Planch.
4
Issued Date
2022-04-01
Resource Type
ISSN
03051978
Scopus ID
2-s2.0-85124240430
Journal Title
Biochemical Systematics and Ecology
Volume
101
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biochemical Systematics and Ecology Vol.101 (2022)
Suggested Citation
Thanasansurapong S., Hongthong S., Saekee A., Chutimasakul T., Wattanakornsiri A., Kongkum N. Resveratrol oligomers from roots of Ampelocissus martini Planch.. Biochemical Systematics and Ecology Vol.101 (2022). doi:10.1016/j.bse.2022.104393 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83292
Title
Resveratrol oligomers from roots of Ampelocissus martini Planch.
Other Contributor(s)
Abstract
Phytochemical investigation of roots of Ampelocissus martini Planch. (Vitaceae family) led to the isolation of five resveratrol oligomers comprising (−)-ampelopsin F (1), (+)-hopeaphenol (2), (−)-α-viniferin (3), (−)-wilsonol A (4) and (−)-stenophyllol B (5). The structure elucidation was performed using their spectroscopic data as well as comparison with those of literature data. All the isolated compounds were submitted to anti-HIV-1 activities employing the syncytium inhibition assay, using the ΔTat/RevMC99 virus and 1A2 cell line system, and the reverse transcriptase (RT) assay. The results revealed that the enzymatic inhibition of tested compounds except compound 1 exhibited the potential inhibition in anti-HIV 1-RT assay with IC50 in the range of 1.68–5.85 μM better than the positive control, navirapin (IC50 at 7.77 μM). Based on the results, their activities displayed the RT enzymatic inhibition better than the positive control. In addition, the chemical isolation of A. martini was studied for the first time herein. All known secondary metabolites except compound 2 were firstly reported from Ampelocissus genus. Furthermore, the chemotaxonomic significance of the isolates was discussed.