Association between gestational diabetes mellitus and periodontitis via the effect of reactive oxygen species in peripheral blood cells
Issued Date
2022-05-01
Resource Type
ISSN
00223492
Scopus ID
2-s2.0-85122404169
Journal Title
Journal of Periodontology
Volume
93
Issue
5
Start Page
758
End Page
769
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Periodontology Vol.93 No.5 (2022) , 758-769
Suggested Citation
Bunpeng N., Boriboonhirunsarn D., Boriboonhirunsarn C., Sawangpanyangkura T., Tansriratanawong K. Association between gestational diabetes mellitus and periodontitis via the effect of reactive oxygen species in peripheral blood cells. Journal of Periodontology Vol.93 No.5 (2022) , 758-769. 769. doi:10.1002/JPER.21-0455 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84450
Title
Association between gestational diabetes mellitus and periodontitis via the effect of reactive oxygen species in peripheral blood cells
Author's Affiliation
Other Contributor(s)
Abstract
Background: Periodontitis (P) has emerged as a risk factor for gestational diabetes mellitus (GDM) through immune cell function alterations, elevated proinflammatory mediators, and increased reactive oxygen species (ROS). The main objective of present study was to determine associations between pregnancy with and without GDM and P. The secondary objective was to compare ROS production in peripheral blood cells (PBCs) of pregnant women with and without GDM. Methods: This cross-sectional case-control study included 128 pregnant women: 64 with and 64 without GDM. All participants were examined for clinical parameters of GDM and periodontal conditions. Associations between GDM-related periodontal data and GDM risk were evaluated by multiple logistic regression. PBCs were isolated and cultured. ROS productions in each PBCs types was investigated by flow cytometry with ROS antibodies. Results: P was significantly more prevalent in pregnant women with GDM than in those without GDM (57.8% versus 37.5%), with an odds ratio (OR) of 2.28, and a 95% confidence interval (CI) of 1.12 to 4.64 (P = 0.022). The OR (95% CI) was 2.59 (1.19 to 5.65) (P = 0.017) after adjusting for potential confounding factors, including diabetes mellitus (DM) family history, age ≥30 years, body mass index, and maternal age. ROS levels in all PBCs types were significantly higher in the GDM than in the non-GDM group (P < 0.05). Conclusion: This study supported the association between P and GDM and indicated that P may be a risk factor for GDM. High levels of ROS production in the PBCs of pregnant women with GDM emphasized the association with GDM.