Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
Issued Date
2022-12-01
Resource Type
eISSN
14752875
Scopus ID
2-s2.0-85137315013
Pubmed ID
36068577
Journal Title
Malaria Journal
Volume
21
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria Journal Vol.21 No.1 (2022)
Suggested Citation
Leonardo L., Kenangalem E., Poespoprodjo J.R., Noviyanti R., Price R.N., Anstey N.M., Minigo G., Kho S. Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria. Malaria Journal Vol.21 No.1 (2022). doi:10.1186/s12936-022-04268-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84850
Title
Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
Other Contributor(s)
Abstract
Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.