Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia
Issued Date
2022-09-01
Resource Type
ISSN
0125877X
eISSN
22288694
Scopus ID
2-s2.0-85136340273
Pubmed ID
31677618
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
40
Issue
3
Start Page
278
End Page
282
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.40 No.3 (2022) , 278-282
Suggested Citation
Janjindamai C., Manuyakorn W., Anurathapan U., Pakakasama S., Wattanasirichaigoon D., Kamchaisatian W., Benjaponpitak S., Hongeng S. Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia. Asian Pacific Journal of Allergy and Immunology Vol.40 No.3 (2022) , 278-282. 282. doi:10.12932/ap-290419-0551 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84921
Title
Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia
Author's Affiliation
Other Contributor(s)
Abstract
Background: HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD). Objective: To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY). Methods: A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of the phagocytic function. He presented with Chromobacterium violaceum liver abscess at the age of 9 months and experienced recurrent perianal abscess and invasive pulmonary aspergillosis even receiving antimicrobial prophylaxis. PTCY was given on day 3 and 4, after CD34+ cells infusion. Results: The peripheral blood-nucleated cell chimerism showed 100% on day 16 and remained 100%. Dihydrorhodamine (DHR) assay on day 108 and day 214 showed normal results. Currently at 22 months post HSCT, he does not receive antibiotic and anti-fungal prophylaxis. Conclusions: Haploidentical HSCT with PTCY could be an effective treatment option for children with CGD.