Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy
4
Issued Date
2022-07-15
Resource Type
ISSN
01448617
Scopus ID
2-s2.0-85127091197
Pubmed ID
35450653
Journal Title
Carbohydrate Polymers
Volume
288
Rights Holder(s)
SCOPUS
Bibliographic Citation
Carbohydrate Polymers Vol.288 (2022)
Suggested Citation
Truong T.H., Alcantara K.P., Bulatao B.P.I., Sorasitthiyanukarn F.N., Muangnoi C., Nalinratana N., Vajragupta O., Rojsitthisak P., Rojsitthisak P. Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy. Carbohydrate Polymers Vol.288 (2022). doi:10.1016/j.carbpol.2022.119401 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85077
Title
Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy
Other Contributor(s)
Abstract
Chitosan (Ch)-coated nanostructured lipid carriers (NLCs) have great potential for transdermal delivery with high localization of chemotherapeutics in breast cancer. This study used tetrahydrocurcumin (THC), a primary metabolite of curcumin with enhanced antioxidant and anticancer properties, as a model compound to prepare NLCs. Response surface methodology was employed to optimize THC-loaded Ch-coated NLCs (THC-Ch-NLCs) fabricated by high-shear homogenization. The optimized THC-Ch-NLCs had particle size of 244 ± 18 nm, zeta potential of −17.5 ± 0.5 mV, entrapment efficiency of 76.6 ± 0.2% and drug loading of 0.28 ± 0.01%. In vitro release study of THC-Ch-NLCs showed sustained release following the Korsmeyer-Peppas model with Fickian and non-Fickian diffusion at pH 7.4 and 5.5, respectively. THC-Ch-NLCs demonstrated significantly enhanced in vitro skin permeation, cell uptake, and remarkable cytotoxicity toward MD-MBA-231 breast cancer cells compared to the unencapsulated THC, suggesting Ch-NLCs as potential transdermal nanocarriers of THC for triple-negative breast cancer treatment.