Association of hypochloremia with mortality among patients requiring continuous renal replacement therapy
3
Issued Date
2023-01-01
Resource Type
ISSN
11218428
eISSN
17246059
Scopus ID
2-s2.0-85127231753
Pubmed ID
35347649
Journal Title
Journal of Nephrology
Volume
36
Issue
1
Start Page
161
End Page
170
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Nephrology Vol.36 No.1 (2023) , 161-170
Suggested Citation
Thongprayoon C., Radhakrishnan Y., Cheungpasitporn W., Petnak T., Zabala Genovez J., Chewcharat A., Qureshi F., Mao M.A., Kashani K.B. Association of hypochloremia with mortality among patients requiring continuous renal replacement therapy. Journal of Nephrology Vol.36 No.1 (2023) , 161-170. 170. doi:10.1007/s40620-022-01305-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85155
Title
Association of hypochloremia with mortality among patients requiring continuous renal replacement therapy
Author's Affiliation
Other Contributor(s)
Abstract
Background: Serum chloride derangement is common in critically ill patients requiring continuous renal replacement therapy (CRRT). We aimed to assess the association between serum chloride levels before and during CRRT with mortality. Methods: This is a retrospective cohort study of critically ill patients receiving CRRT for acute kidney injury from December 2006 through November 2015 in a tertiary referral hospital in the United States. We used logistic regression to assess serum chloride before and mean serum chloride during CRRT as predictors for 90 days mortality after CRRT initiation. The normal reference range for serum chloride was 99–108 mmol/L. Results: Of 1282 eligible patients, 25%, 50%, and 25% had hypochloremia, normochloremia, and hyperchloremia, respectively. The adjusted odds ratio for 90 days mortality in patients with hypochloremia before CRRT was 1.82 (95% CI 1.29–2.55). During CRRT, 4%, 70%, 26% of patients had mean serum chloride in the hypochloremia, normochloremia, and hyperchloremia range, respectively. The adjusted odds ratio for 90 days mortality in patients with mean serum chloride during CRRT in the hypochloremia range was 2.96 (95% CI 1.43–6.12). Hyperchloremia before and during CRRT was not associated with mortality. The greater serum chloride range during CRRT was associated with increased mortality (OR 1.29; 95% CI 1.13–1.47 per 5 mmol/L increase). Conclusion: Hypochloremia before and during CRRT is associated with higher mortality. Graphical abstract: [Figure not available: see fulltext.]