Dental Screening Including Panoramic Radiograph for Gorlin-Goltz Syndrome in Patients With Multiple Basal Cell Carcinomas
2
Issued Date
2022-11-01
Resource Type
ISSN
12034754
Scopus ID
2-s2.0-85139625621
Pubmed ID
36205130
Journal Title
Journal of Cutaneous Medicine and Surgery
Volume
26
Issue
6
Start Page
586
End Page
592
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Cutaneous Medicine and Surgery Vol.26 No.6 (2022) , 586-592
Suggested Citation
Pitak-Arnnop P., Witohendro L.K., Tangmanee C., Bhakdinaronk A., Subbalekha K., Auychai P., Sirintawat N., Meningaud J.P., Neff A. Dental Screening Including Panoramic Radiograph for Gorlin-Goltz Syndrome in Patients With Multiple Basal Cell Carcinomas. Journal of Cutaneous Medicine and Surgery Vol.26 No.6 (2022) , 586-592. 592. doi:10.1177/12034754221128798 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85418
Title
Dental Screening Including Panoramic Radiograph for Gorlin-Goltz Syndrome in Patients With Multiple Basal Cell Carcinomas
Other Contributor(s)
Abstract
Purpose: To answer the following clinical research question: “Among patients with multiple basal cell carcinomas (mBCCs), can panoramic radiograph (PaR) facilitate the diagnosis of Gorlin-Goltz syndrome (GGS)?” Methods: This retrospective study enrolled mBCCs subjects who presented to a German tertiary care center between 1 January 2015 and 31 December 2021. The primary predictor was presence of syndromic mBCCs, and the main outcomes were jaw cysts and odontogenic keratocysts (OKCs). Descriptive, bi- and multivariate statistics, diagnostic test evaluation, and number needed to screen (NNS) were computed at α = 95%. Results: The sample comprised 527 mBCCs patients (36.1% females; 6.8% GGS; 5.5% OKCs; mean age, 74.5 ± 15.8 years [range, 15-102]). There was a significant association between syndromic mBCCs and jaw cysts (P <.0001; NNS = 2 [95% CI, CI, 1.1 to 1.4]). In the adjusted logistic model, PaR identified GGS via radiographic diagnosis of jaw cysts in case of 1) age ≤ 35 years, 2) ≥ 5 BCCs, and 3) ≥ 1 high-risk BCCs. Nearly every jaw cyst identified by PaR was OKCs (P =.01; 95% CI, 3.1 to 3,101.4; NNS = 1.3 [95% CI,.9 to 2]). The post hoc power was 100%. Conclusions: Dental screening with the use of PaR for mBCCs patients, especially those aged ≤35 years, or with ≥5 BCCs, or ≥1 high-risk BCCs, may be helpful in detection and identification of GGS through recognition of OKCs.