The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study
Issued Date
2022-09-01
Resource Type
ISSN
09031936
eISSN
13993003
Scopus ID
2-s2.0-85138446829
Pubmed ID
35144987
Journal Title
European Respiratory Journal
Volume
60
Issue
3
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Respiratory Journal Vol.60 No.3 (2022)
Suggested Citation
García-Marcos L., Asher M.I., Pearce N., Ellwood E., Bissell K., Chiang C.Y., El Sony A., Ellwood P., Marks G.B., Mortimer K., Martínez-Torres A.E., Morales E., Perez-Fernandez V., Robertson S., Rutter C.E., Silverwood R.J., Strachan D.P., Masekela R., Badellino H., Urrutia-Pereira M., Ndikum A.E., Mallol J., Soto-Martínez M.E., Cabrera Aguilar A., Douros K., Sosa Ferrari S.M., Mohammad S., Singh M., Singh V., Ghoshal A.G., Sukumaran T.U., Awasthi S., Mahesh P.A., Kabra S.K., Salvi S., Tavakol M., Behniafard N., Alomary S.A., Bucaliu-Ismajli I., Pajaziti L., Gashi V., Kurhasani X., Gacaferri-Lumezi B., Ahmetaj L.N., Zhjeqi V., Sanchez Coronel M.G., Moreno Gardea H.L., Ochoa-Lopez G., García-Almaráz R., Sacre Hazouri J.A., Rodriguez-Perez N., Mérida-Palacio J.V., Del Río Navarro B.E., Hernández-Mondragón L.O., González-Díaz S.N., Garcia-Muñoz R., Pineda M.J., García B.R., Escalante-Dominguez A.J., Linares-Zapién F.J., Navarrete-Rodriguez E.M., Santos Lozano J., Asher I., Sánchez J.F., Falade A.G., Brożek G., Kyzmicheva K., Zar H.J., López-Silvarrey Varela A., González Díaz C., Bercedo Sanz A., Pellegrini Belinchon J., Ranasinghe J.C., Kudagammana S.T., El Sadig H., Nour M., Alkhayer G., Dib G., Mohammad Y., Huang J., Chinratanapisit S., Solé D., Soto-Quirós M.E., Althagafi W.A., Vichyanond P. The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study. European Respiratory Journal Vol.60 No.3 (2022). doi:10.1183/13993003.02866-2021 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85556
Title
The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study
Author(s)
García-Marcos L.
Asher M.I.
Pearce N.
Ellwood E.
Bissell K.
Chiang C.Y.
El Sony A.
Ellwood P.
Marks G.B.
Mortimer K.
Martínez-Torres A.E.
Morales E.
Perez-Fernandez V.
Robertson S.
Rutter C.E.
Silverwood R.J.
Strachan D.P.
Masekela R.
Badellino H.
Urrutia-Pereira M.
Ndikum A.E.
Mallol J.
Soto-Martínez M.E.
Cabrera Aguilar A.
Douros K.
Sosa Ferrari S.M.
Mohammad S.
Singh M.
Singh V.
Ghoshal A.G.
Sukumaran T.U.
Awasthi S.
Mahesh P.A.
Kabra S.K.
Salvi S.
Tavakol M.
Behniafard N.
Alomary S.A.
Bucaliu-Ismajli I.
Pajaziti L.
Gashi V.
Kurhasani X.
Gacaferri-Lumezi B.
Ahmetaj L.N.
Zhjeqi V.
Sanchez Coronel M.G.
Moreno Gardea H.L.
Ochoa-Lopez G.
García-Almaráz R.
Sacre Hazouri J.A.
Rodriguez-Perez N.
Mérida-Palacio J.V.
Del Río Navarro B.E.
Hernández-Mondragón L.O.
González-Díaz S.N.
Garcia-Muñoz R.
Pineda M.J.
García B.R.
Escalante-Dominguez A.J.
Linares-Zapién F.J.
Navarrete-Rodriguez E.M.
Santos Lozano J.
Asher I.
Sánchez J.F.
Falade A.G.
Brożek G.
Kyzmicheva K.
Zar H.J.
López-Silvarrey Varela A.
González Díaz C.
Bercedo Sanz A.
Pellegrini Belinchon J.
Ranasinghe J.C.
Kudagammana S.T.
El Sadig H.
Nour M.
Alkhayer G.
Dib G.
Mohammad Y.
Huang J.
Chinratanapisit S.
Solé D.
Soto-Quirós M.E.
Althagafi W.A.
Vichyanond P.
Asher M.I.
Pearce N.
Ellwood E.
Bissell K.
Chiang C.Y.
El Sony A.
Ellwood P.
Marks G.B.
Mortimer K.
Martínez-Torres A.E.
Morales E.
Perez-Fernandez V.
Robertson S.
Rutter C.E.
Silverwood R.J.
Strachan D.P.
Masekela R.
Badellino H.
Urrutia-Pereira M.
Ndikum A.E.
Mallol J.
Soto-Martínez M.E.
Cabrera Aguilar A.
Douros K.
Sosa Ferrari S.M.
Mohammad S.
Singh M.
Singh V.
Ghoshal A.G.
Sukumaran T.U.
Awasthi S.
Mahesh P.A.
Kabra S.K.
Salvi S.
Tavakol M.
Behniafard N.
Alomary S.A.
Bucaliu-Ismajli I.
Pajaziti L.
Gashi V.
Kurhasani X.
Gacaferri-Lumezi B.
Ahmetaj L.N.
Zhjeqi V.
Sanchez Coronel M.G.
Moreno Gardea H.L.
Ochoa-Lopez G.
García-Almaráz R.
Sacre Hazouri J.A.
Rodriguez-Perez N.
Mérida-Palacio J.V.
Del Río Navarro B.E.
Hernández-Mondragón L.O.
González-Díaz S.N.
Garcia-Muñoz R.
Pineda M.J.
García B.R.
Escalante-Dominguez A.J.
Linares-Zapién F.J.
Navarrete-Rodriguez E.M.
Santos Lozano J.
Asher I.
Sánchez J.F.
Falade A.G.
Brożek G.
Kyzmicheva K.
Zar H.J.
López-Silvarrey Varela A.
González Díaz C.
Bercedo Sanz A.
Pellegrini Belinchon J.
Ranasinghe J.C.
Kudagammana S.T.
El Sadig H.
Nour M.
Alkhayer G.
Dib G.
Mohammad Y.
Huang J.
Chinratanapisit S.
Solé D.
Soto-Quirós M.E.
Althagafi W.A.
Vichyanond P.
Author's Affiliation
Pushpagiri Institute of Medical Sciences and Research Centre
College of Medicine
Liverpool University Hospitals NHS Foundation Trust
Department of Medicine
JSS Medical College & Hospital, Mysuru
Alborz University of Medical Sciences
Syrian Private University
Universidade Federal do Pampa
Faculty of Medical and Health Sciences
Tishreen University
Taipei Municipal Wan-Fang Hospital
Universidad de Costa Rica
University of Peradeniya
Université de Yaoundé I
Universiteti i Prishtinës
Ministry of Health Saudi Arabia
London School of Hygiene & Tropical Medicine
Hospital Clínico Universitario Virgen de la Arrixaca
St George’s, University of London
South African Medical Research Council
National and Kapodistrian University of Athens
UNSW Sydney
Universidad del Pais Vasco
Slaski Uniwersytet Medyczny w Katowicach
Universidad Autónoma de Nuevo León
Universidad de Salamanca
Universidad Regional del Sureste
International Union Against Tuberculosis and Lung Disease
Universidad de Santiago de Chile
Bhumibol Adulyadej Hospital
Tyumen State Medical University
King George's Medical University
College of Health Sciences
Chang Gung University
University College Hospital, Ibadan
Universidade Federal de São Paulo
Mahidol University
All India Institute of Medical Sciences, New Delhi
Universidad de Guadalajara
Instituto Mexicano del Seguro Social
Shahid Sadoughi University of Medical Sciences
UCL Institute of Education
The University of Auckland
Hospital Infantil de Mexico Federico Gomez
Postgraduate Institute of Medical Education & Research, Chandigarh
Universidad de Murcia
Medica San Angel
Respiraclinic
University of Prishtina
UBT College Kosovo
COMPEDIA (Colegio Mexicano de Pediatras Especialistas en Inmunología y Alergia)
The Principal Center of Family Care
CRIT de Michoacán
American Hospital in Kosovo
UCES University and Clínica Regional del Este
Hospital Infantil de Tamaulipas
Dobra Health Center
ARADyAL Allergy Network
Kothari Medical and Research Institute
Ministry of Health
Centro de Investigacion de Enfermedades Alergicas y Respiratorias
Centro De Enfermedades Alergicas Y Asma de Toluca
Research and Development
IMIB Bio-health Research Institute
University of Prishtina
University Hospital Clinical Services
Instituto Nacional Cardiopulmonar
Teaching Hospital
Instituto de Ciencias y Estudios Superiores de Tamaulipas
Asthma Bhawan
National Allergy Asthma Bronchitis Institute
Hospital General Tijuana
Instituto Privado de Alergia
Hospital Ángeles Chihuahua
Epi-Lab
Fundación María José Jove
Chest Research Foundation
Hospital Infantil Manuel de Jesus Rivera
College of Medicine
Liverpool University Hospitals NHS Foundation Trust
Department of Medicine
JSS Medical College & Hospital, Mysuru
Alborz University of Medical Sciences
Syrian Private University
Universidade Federal do Pampa
Faculty of Medical and Health Sciences
Tishreen University
Taipei Municipal Wan-Fang Hospital
Universidad de Costa Rica
University of Peradeniya
Université de Yaoundé I
Universiteti i Prishtinës
Ministry of Health Saudi Arabia
London School of Hygiene & Tropical Medicine
Hospital Clínico Universitario Virgen de la Arrixaca
St George’s, University of London
South African Medical Research Council
National and Kapodistrian University of Athens
UNSW Sydney
Universidad del Pais Vasco
Slaski Uniwersytet Medyczny w Katowicach
Universidad Autónoma de Nuevo León
Universidad de Salamanca
Universidad Regional del Sureste
International Union Against Tuberculosis and Lung Disease
Universidad de Santiago de Chile
Bhumibol Adulyadej Hospital
Tyumen State Medical University
King George's Medical University
College of Health Sciences
Chang Gung University
University College Hospital, Ibadan
Universidade Federal de São Paulo
Mahidol University
All India Institute of Medical Sciences, New Delhi
Universidad de Guadalajara
Instituto Mexicano del Seguro Social
Shahid Sadoughi University of Medical Sciences
UCL Institute of Education
The University of Auckland
Hospital Infantil de Mexico Federico Gomez
Postgraduate Institute of Medical Education & Research, Chandigarh
Universidad de Murcia
Medica San Angel
Respiraclinic
University of Prishtina
UBT College Kosovo
COMPEDIA (Colegio Mexicano de Pediatras Especialistas en Inmunología y Alergia)
The Principal Center of Family Care
CRIT de Michoacán
American Hospital in Kosovo
UCES University and Clínica Regional del Este
Hospital Infantil de Tamaulipas
Dobra Health Center
ARADyAL Allergy Network
Kothari Medical and Research Institute
Ministry of Health
Centro de Investigacion de Enfermedades Alergicas y Respiratorias
Centro De Enfermedades Alergicas Y Asma de Toluca
Research and Development
IMIB Bio-health Research Institute
University of Prishtina
University Hospital Clinical Services
Instituto Nacional Cardiopulmonar
Teaching Hospital
Instituto de Ciencias y Estudios Superiores de Tamaulipas
Asthma Bhawan
National Allergy Asthma Bronchitis Institute
Hospital General Tijuana
Instituto Privado de Alergia
Hospital Ángeles Chihuahua
Epi-Lab
Fundación María José Jove
Chest Research Foundation
Hospital Infantil Manuel de Jesus Rivera
Other Contributor(s)
Abstract
Aims There have been no worldwide standardised surveys of prevalence and severity of asthma, rhinoconjunctivitis and eczema in school children for 15 years. The present study aims to provide this information. Methods Following the exact International Study of Asthma and Allergies in Childhood (ISAAC) methodology (cross-sectional questionnaire-based survey), Global Asthma Network (GAN) Phase I was carried out between 2015 and 2020 in many centres worldwide. Results The study included 157784 adolescents (13-14 years of age) in 63 centres in 25 countries and 101777 children (6-7 years of age) in 44 centres in 16 countries. The current prevalence of symptoms, respectively, was 11.0% and 9.1% for asthma, 13.3% and 7.7% for rhinoconjunctivitis and 6.4% and 5.9% for eczema. The prevalence of asthma ever was 10.5% and 7.6%, hay fever ever was 15.2% and 11.1% and eczema ever was 10.6% and 13.4%, respectively. Centres in low or lower middle gross national income countries (LICs or LMICs) had significantly lower prevalence of the three disease symptoms and diagnoses (except for hay fever). In children, the prevalence of asthma and rhinoconjunctivitis symptoms was higher in boys, while the reverse occurred among adolescents. For eczema, while the prevalence among female adolescents was double that of males, there was no sex difference among children. Centre accounted for non-negligible variability in all disease symptoms (10-20%). Conclusion The burdens of asthma, rhinoconjunctivitis and eczema vary widely among the limited number of countries studied. Although symptom prevalence is lower in LICs and LMICs, it represents a considerable burden everywhere studied.