Circulating trophoblast numbers as a potential marker for pregnancy complications
Issued Date
2022-08-01
Resource Type
ISSN
01973851
eISSN
10970223
DOI
Scopus ID
2-s2.0-85133197620
Pubmed ID
35765264
Journal Title
Prenatal Diagnosis
Volume
42
Issue
9
Start Page
1182
End Page
1189
Rights Holder(s)
SCOPUS
Bibliographic Citation
Prenatal Diagnosis Vol.42 No.9 (2022) , 1182-1189
Suggested Citation
Crovetti B., Maktabi M.A., Erfani H., Panchalee T., Wang Q., Vossaert L., Van den Veyver I. Circulating trophoblast numbers as a potential marker for pregnancy complications. Prenatal Diagnosis Vol.42 No.9 (2022) , 1182-1189. 1189. doi:10.1002/pd.6202 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85681
Title
Circulating trophoblast numbers as a potential marker for pregnancy complications
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To explore the potential of circulating trophoblasts (TBs) as a non-invasive tool to assess placental health and predict obstetric complications. Methods: We retrospectively reviewed maternal characteristics and pregnancy outcomes of 369 women who enrolled in our original cell-based NIPT (cbNIPT) study. The number of circulating TBs recovered from the maternal blood samples was recorded and expressed as fetal cell concentration (FCC). We evaluated if FCC can be used to predict pregnancy outcomes such as hypertensive disorders of pregnancy (HDP), fetal growth restriction, placental abruption, preterm labor, and pregnancy loss. Results: Receiver operating characteristic (ROC) analysis was performed to find the best cut off value to classify FCC into a low and high FCC group, and this cut-off point was calculated as 11.1 cells per 100 ml of blood. The adjusted odds ratio (aOR) for the composite morbidity was significantly increased for the high FCC group at an aOR of 1.6. Conclusion: Circulating TB have the potential of predicting obstetrical complications such as HDP. Future studies, with larger sample sizes, should focus on the study of these cells as a biomarker for placental health and a possible screening or diagnostic tool for fetal genetic conditions.