Viral hepatitis and the cascade of care among people living with HIV in the Asia-Pacific
3
Issued Date
2022-01-01
Resource Type
ISSN
14642662
eISSN
14681293
Scopus ID
2-s2.0-85125381090
Pubmed ID
35218151
Journal Title
HIV Medicine
Rights Holder(s)
SCOPUS
Bibliographic Citation
HIV Medicine (2022)
Suggested Citation
Rupasinghe D., Choi J.Y., Kumarasamy N., Pujari S., Sun L.P., Merati T.P., Lee M.P., Kinh N.V., Kiertiburanakul S., Do C.D., Avihingsanon A., Ross J., Jiamsakul A. Viral hepatitis and the cascade of care among people living with HIV in the Asia-Pacific. HIV Medicine (2022). doi:10.1111/hiv.13280 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86659
Title
Viral hepatitis and the cascade of care among people living with HIV in the Asia-Pacific
Author's Affiliation
The Voluntary Health Services, Chennai
Bach Mai Hospital
Universitas Udayana
The Kirby Institute
Yonsei University College of Medicine
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Queen Elizabeth Hospital Hong Kong
Faculty of Medicine, Chulalongkorn University
National Hospital for Tropical Diseases
National Center for HIV/AIDS
amfAR - The Foundation for AIDS Research
Institute of Infectious Diseases
Bach Mai Hospital
Universitas Udayana
The Kirby Institute
Yonsei University College of Medicine
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Queen Elizabeth Hospital Hong Kong
Faculty of Medicine, Chulalongkorn University
National Hospital for Tropical Diseases
National Center for HIV/AIDS
amfAR - The Foundation for AIDS Research
Institute of Infectious Diseases
Other Contributor(s)
Abstract
Background: Although the prevalence and mortality of hepatitis is high in the Asia-Pacific region, few studies are available on the diagnosis, treatment, and cure rates for viral hepatitis among people living with HIV in this area. This study aims to report the cascade of care (CoC) for hepatitis B (HBV) and C (HCV) among people living with HIV receiving combined antiretroviral therapy (ART). Methods: Patients enrolled in the TREAT Asia HIV Observational Database Low Intensity Transfer (TAHOD-LITE) cohort, on ART, and with follow-up data from 2010 to 2019 were included. Patients were determined as positive for HCV or HBV co-infection if they ever tested positive for HCV antibody (anti-HCV) or HBV surface antigen (HBsAg), respectively. Results: In total, 39% (8612/22 340) of the adult HIV cohort had undergone HBsAg testing, with 8% (672/8612) testing positive. HBV CoC demonstrated that 71% (474/672) of those with HBsAg positive results initiated treatment, 67% (318/474) of those on treatment had HBV DNA testing to evaluate treatment progression, and 18% (58/318) of those tested reached viral suppression. Of the cohort, 37% (8231/22 340) had anti-HCV testing, of whom 10% (779/8231) tested positive. The HCV CoC showed that 68% (526/779) of those with positive anti-HCV tests had HCV RNA tests, of whom 51% (267/526) had detectable HCV RNA. Among those with detectable HCV RNA, 65% (174/267) initiated HCV treatment. Of the 40% (69/174) who initiated HCV treatment, 90% (62/69) reached sustained virological response. Conclusion: Our findings identified less frequent testing in the healthcare system and limited access to treatment as gaps in the CoC for viral hepatitis. More routine HCV RNA and HBV DNA testing is required for patients with positive screening tests to identify those in need of treatment.