Direct immunofluorescence staining patterns compared between oral and cutaneous lichen planus
2
Issued Date
2022-02-01
Resource Type
ISSN
03076938
eISSN
13652230
Scopus ID
2-s2.0-85114881247
Pubmed ID
34382241
Journal Title
Clinical and Experimental Dermatology
Volume
47
Issue
2
Start Page
389
End Page
393
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical and Experimental Dermatology Vol.47 No.2 (2022) , 389-393
Suggested Citation
Rujitharanawong C. Direct immunofluorescence staining patterns compared between oral and cutaneous lichen planus. Clinical and Experimental Dermatology Vol.47 No.2 (2022) , 389-393. 393. doi:10.1111/ced.14879 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87385
Title
Direct immunofluorescence staining patterns compared between oral and cutaneous lichen planus
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
This retrospective study performed to investigate direct immunofluorescence (DIF) findings in oral and cutaneous lichen planus (LP), and to identify any differences between them. There were 147 patients with a definite diagnosis of LP by clinical and histological criteria, with 87 (59.2%) oral and 60 (40.8%) cutaneous specimens. Of these, 125 (85%) had positive DIF findings, with positive yields being significantly lower in oral (79.3%) than in cutaneous (93.3%) LP. Deposition of immunoreactants at the dermoepidermal junction (DEJ) was significantly greater in oral than in cutaneous LP, and fibrin deposition with shaggy pattern at the DEJ was also significantly greater in oral than in cutaneous LP. Deposition of immunoreactants at colloid bodies (CBs) with or without DEJ was significantly greater in cutaneous than in oral LP. IgM deposition at CBs was commonly detected in both groups. We propose that fibrin deposition with shaggy pattern at the DEJ is the best diagnostic indicator of oral LP.