Disagreement of Radial Peripapillary Capillary Density Among Four Optical Coherence Tomography Angiography Devices
Issued Date
2023-08-01
Resource Type
eISSN
21642591
Scopus ID
2-s2.0-85167371958
Pubmed ID
37555736
Journal Title
Translational vision science & technology
Volume
12
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Translational vision science & technology Vol.12 No.8 (2023) , 7
Suggested Citation
Sawaspadungkij M., Apinyawasisuk S., Suwan Y., Fard M.A., Sahraian A., Jalili J., Chansangpetch S. Disagreement of Radial Peripapillary Capillary Density Among Four Optical Coherence Tomography Angiography Devices. Translational vision science & technology Vol.12 No.8 (2023) , 7. doi:10.1167/tvst.12.8.7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/88351
Title
Disagreement of Radial Peripapillary Capillary Density Among Four Optical Coherence Tomography Angiography Devices
Other Contributor(s)
Abstract
Purpose: This prospective study evaluated the agreement among four optical coherence tomography angiography (OCTA) devices in the assessment of radial peripapillary capillary (RPC) density. Methods: The study included 48 eyes of 48 subjects (14 healthy, 19 glaucomatous, and 15 non-glaucomatous optic neuropathy). Each participant was scanned using four OCTA devices in a random sequence: RTVue XR Avanti (RTVue), DRI OCT Triton (Triton), Revo NX 130 (Revo), and PLEX Elite 9000 (PlexE). All 6 × 6-mm grayscale OCTA images from each device were analyzed for RPC density using a customized algorithm. Agreement between each pair of devices was assessed using intraclass correlation coefficients (ICCs) and Bland-Altman plots. Results: There was a poor correlation between devices in all comparisons (RTVue-Triton, ICC = 0.34; RTVue-Revo, ICC = 0.31; RTVue-PlexE, ICC = 0.28; Triton-Revo, ICC = 0.31; Triton-PlexE, ICC = 0.17; Revo-PlexE, ICC = 0.34). Significant proportional biases (P < 0.05) and wide limits of agreement with apparent constant biases were identified in all comparisons. The mean difference was greatest for the RTVue-Revo pair (-49.3%; 95% confidence interval [CI], -52.9 to -45.8) and smallest for the Triton-PlexE pair (-7.7%; 95% CI, -10.1 to -5.3). Conclusions: The RPC densities obtained from each device had poor inter-device agreement and significant biases and cannot be used interchangeably. Translational Relevance: RPC density obtained from different OCTA devices is not interchangeable; thus, the progression of optic neuropathy should be monitored using the same OCTA device.