Self- and physician-collected high-risk human papillomavirus (HPV) testing to detect high-grade cervical lesions among Thai women
4
Issued Date
2023-09-04
Resource Type
eISSN
15251438
Scopus ID
2-s2.0-85169848119
Pubmed ID
37612037
Journal Title
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Volume
33
Issue
9
Start Page
1354
End Page
1358
Rights Holder(s)
SCOPUS
Bibliographic Citation
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Vol.33 No.9 (2023) , 1354-1358
Suggested Citation
Phoolcharoen N., Areeruk W., Kantathavorn N., Tiyayon J., Chittithaworn S., Wetcho T., Satitniramai S., Khomphaiboonkij U., Pitakkarnkul S., Termrungruanglert W., Srisomboon J., Tangjitgamol S. Self- and physician-collected high-risk human papillomavirus (HPV) testing to detect high-grade cervical lesions among Thai women. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Vol.33 No.9 (2023) , 1354-1358. 1358. doi:10.1136/ijgc-2023-004424 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90004
Title
Self- and physician-collected high-risk human papillomavirus (HPV) testing to detect high-grade cervical lesions among Thai women
Other Contributor(s)
Abstract
OBJECTIVE: We compared the performance of high-risk human papillomavirus (HPV) messenger RNA testing of physician- and self-collected specimens for detecting histological grade 2 or higher cervical intraepithelial neoplasia (CIN) among women who visited a colposcopy clinic in Thailand. METHODS: From January 2022 to April 2022, 500 women participated in this cross-sectional multicenter study; 494 had complete data and valid specimen results. The participants were women who attended any one of the 10 participating institutes' colposcopy clinics due to abnormal cytology, positive high-risk HPV testing, or for follow-up. Participants used a self-sampling Aptima Multitest Swab specimen collection kit to self-collect vaginal samples before physicians biopsied the cervix during the colposcopic examination. The self- and physician-collected specimens were tested for high-risk HPV messenger RNA using Aptima nucleic acid amplification assays. Cervical tissues were collected during colposcopic-directed biopsy from the most severe lesion or a random biopsy and endocervical curettage specimen if no lesion was detected. RESULTS: We detected high-risk HPV messenger RNA in 75.4% of self-collected specimens and 70.6% of physician-collected specimens. The prevalence of histological grade 2 or higher CIN from cervical histology was 25.1% (n=124). For self-collected specimens, the sensitivity and specificity of high-risk HPV messenger RNA for grade 2 or higher CIN were 87.0% (95% CI 79.7% to 92.4%; n=108) and 28.5% (95% CI 24.0% to 33.4%). For physician-collected specimens, the sensitivity and specificity of high-risk HPV messenger RNA for grade 2 or higher CIN were 90.2% (95% CI 83.6% to 94.9%; n=112) and 36.1% (95% CI 31.2% to 41.3%). CONCLUSIONS: Self-collected specimens for high-risk HPV messenger RNA testing demonstrated good sensitivity and negative predictive value for detecting grade 2 or higher CIN in Thai women attending the participating institutes' colposcopy clinics. Self-collected samples performed similarly to physician-collected ones.