Two Case Reports of Elastolytic Giant Cell Granuloma on the Palms
1
Issued Date
2023-01-01
Resource Type
eISSN
11787015
Scopus ID
2-s2.0-85171993983
Journal Title
Clinical, Cosmetic and Investigational Dermatology
Volume
16
Start Page
2497
End Page
2502
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical, Cosmetic and Investigational Dermatology Vol.16 (2023) , 2497-2502
Suggested Citation
Promsena P., Triyangkulsri K., Rutnin S. Two Case Reports of Elastolytic Giant Cell Granuloma on the Palms. Clinical, Cosmetic and Investigational Dermatology Vol.16 (2023) , 2497-2502. 2502. doi:10.2147/CCID.S422554 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90277
Title
Two Case Reports of Elastolytic Giant Cell Granuloma on the Palms
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Elastolytic giant cell granuloma (EGCG) is a rare granulomatous reaction hypothesized to occur because of the altered antigenicity of elastic fibers, resulting in cellular immunological reactions. The hallmarks of EGCG include elastolysis, elastophago-cytosis, and multinucleated giant cell infiltrations. EGCG was first described as an actinic granuloma or annular elastolytic giant cell granuloma that classically presents as centrifugally expanding annular plaques on sun-exposed areas. It was recently named EGCG due to reports of non-annular lesions in various sun-protected areas. Hand involvement has been described but is almost exclusively confined to the dorsal and lateral aspects of the hands. Herein, we report two cases of EGCG on the palms, an unusual site of presentation, that were successfully treated with topical, high-potency corticosteroids. EGCG should be included in the differential diagnosis in cases of annular skin lesions located on the marginal area of the palms.