Familial clustering of nonalcoholic fatty liver disease in first-degree relatives of adults with lean nonalcoholic fatty liver disease
2
Issued Date
2023-01-01
Resource Type
ISSN
14783223
eISSN
14783231
Scopus ID
2-s2.0-85173440436
Pubmed ID
37804066
Journal Title
Liver International
Rights Holder(s)
SCOPUS
Bibliographic Citation
Liver International (2023)
Suggested Citation
Niltwat S., Limwongse C., Charatcharoenwitthaya N., Bunditvorapoom D., Bandidniyamanon W., Charatcharoenwitthaya P. Familial clustering of nonalcoholic fatty liver disease in first-degree relatives of adults with lean nonalcoholic fatty liver disease. Liver International (2023). doi:10.1111/liv.15758 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90580
Title
Familial clustering of nonalcoholic fatty liver disease in first-degree relatives of adults with lean nonalcoholic fatty liver disease
Author's Affiliation
Other Contributor(s)
Abstract
Background and Aims: The heritability of nonalcoholic fatty liver disease (NAFLD) in lean individuals is undetermined. This familial aggregation study aimed to evaluate familial linkage for NAFLD and the risk of NAFLD among first-degree relatives of probands with lean NAFLD. Methods: This study prospectively recruited cohorts of probands with lean NAFLD, probands with obese NAFLD, and lean probands with non-NAFLD and their respective first-degree relatives. A total of 257 participants were evaluated for liver steatosis, defined by the controlled attenuation parameter ≥288 dB/m2, metabolic characteristics, and the PNPLA3, TM6SF2, and MBOAT7 polymorphisms. Results: The prevalence of NAFLD in first-degree relatives of lean NAFLD probands (39.9%) was similar to that in the obese NAFLD group (36.9%) and was significantly higher than in lean persons without NAFLD (19.1%). First-degree relatives of probands with NAFLD who were male, and had central obesity, hypertriglyceridaemia, insulin resistance, and the PNPLA3 rs738409C>G allele had a significantly higher prevalence of NAFLD. After multivariable adjustment for gender, metabolic characteristics, and the PNPLA3 rs738409C>G allele, first-degree relatives of probands with lean NAFLD (odds ratio [OR], 5.13; 95% CI, 1.77–14.86) and obese NAFLD (OR, 3.20; 95% CI, 1.14–8.99) exhibited an increased risk of NAFLD compared with those of lean controls without NAFLD. Conclusions: Our well-phenotype cohorts revealed familial clustering of NAFLD and higher risks of NAFLD in first-degree relatives of probands with lean or obese NAFLD. The findings encourage clinicians caring for NAFLD patients to be more vigilant for NAFLD in their family members.