Biochemical aspects of the inflammatory process: A narrative review
6
Issued Date
2023-12-01
Resource Type
ISSN
07533322
eISSN
19506007
Scopus ID
2-s2.0-85174895477
Journal Title
Biomedicine and Pharmacotherapy
Volume
168
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomedicine and Pharmacotherapy Vol.168 (2023)
Suggested Citation
Soares C.L.R., Wilairatana P., Silva L.R., Moreira P.S., Vilar Barbosa N.M.M., da Silva P.R., Coutinho H.D.M., de Menezes I.R.A., Felipe C.F.B. Biochemical aspects of the inflammatory process: A narrative review. Biomedicine and Pharmacotherapy Vol.168 (2023). doi:10.1016/j.biopha.2023.115764 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90903
Title
Biochemical aspects of the inflammatory process: A narrative review
Other Contributor(s)
Abstract
Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical, and physiological changes that trigger the release of pro-inflammatory chemical mediators at the local of the injured site thus, increasing blood flow, vascular permeability, and leukocyte recruitment. The aim of this study is to give an overview of the inflammatory process, focusing on chemical mediators. The literature review was based on a search of journals published between the years 2009 and 2023, regarding the role of major chemical mediators in the inflammatory process and current studies in pathogenesis, diagnosis, and therapy. Some of the recent contributions in the study of inflammatory pathologies and their mediators, including cytokines and chemokines, the kinin system, free radicals, nitric oxide, histamine, cell adhesion molecules, leukotrienes, prostaglandins and the complement system and their role in human health and chronic diseases.