Publication: Liver profile changes and complications in jaundiced patients with falciparum malaria
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Issued Date
1994-12-01
Resource Type
ISSN
01772392
Other identifier(s)
2-s2.0-0028670630
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Medicine and Parasitology. Vol.45, No.4 (1994), 298-302
Suggested Citation
P. Wilairatana, S. Looareesuwan, P. Charoenlarp Liver profile changes and complications in jaundiced patients with falciparum malaria. Tropical Medicine and Parasitology. Vol.45, No.4 (1994), 298-302. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9566
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Title
Liver profile changes and complications in jaundiced patients with falciparum malaria
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Abstract
To demonstrate the liver profile abnormalities in jaundiced falciparum malaria patients and to determine whether jaundice was associated with other complications in falciparum malaria, 390 patients with acute falciparum malaria were studied. 124 patients were jaundiced and the others were nonjaundiced. Hyperbilirubinemia (total serum bilirubin 3 to 64 mg/dl) was found in jaundiced patients predominantly as unconjugated bilirubin. Asparatate aminotransferase and alanine minotransferase were significantly higher in jaundiced patients (p < 0.01). There was a slight decrease of serum albumin in jaundiced malaria. The complications in jaundiced patients included cerebral malaria (n = 10), acute renal failure (n = 12), pulmonary edema (n = 3), shock (n = 3), and other severe malarial complications (n = 43). Jaundice was associated with cerebral malaria (p < 0.05), acute renal failure (p < 0.01), and hyperparasitemia (p < 0.01). After successful treatment, liver profile returned to normal within a few weeks. We found that jaundiced malaria patients had transient liver profile impairment which indicated predominantly hemolysis rather than liver damage; complications were more frequent in jaundiced patients.