Publication: Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives
1
Issued Date
1994-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0028228429
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, (1994), 41-43
Suggested Citation
Nicholas J. White Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, (1994), 41-43. doi:10.1016/0035-9203(94)90471-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9604
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Title
Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives
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Abstract
Reliable and reproducible methods for the measurement of artemisinin and its derivatives in body fluids have proved difficult to develop. The available evidence suggests that all compounds are hydrolysed to a biologically active metabolite, dihydroartemisinin, which is eliminated rapidly. The role of other (hydroxylated) metabolites in humans requires further study. The hydrolysis of artesunate is so rapid that it may be considered a pro-drug for dihydroartemisinin. All the artemisinin compounds induce more rapid reduction of parasitaemia than other antimalarial drugs, indicating a direct effect on ring forms. This pharmacodynamic measure can be used in drug comparisons, and allows estimations of the number of parasites removed before sequestration. © 1994 Oxford University Press.