Extracellular Vesicles for Childhood Cancer Liquid Biopsy
1
Issued Date
2024-05-01
Resource Type
eISSN
20726694
Scopus ID
2-s2.0-85192508738
Journal Title
Cancers
Volume
16
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cancers Vol.16 No.9 (2024)
Suggested Citation
Singhto N., Pongphitcha P., Jinawath N., Hongeng S., Chutipongtanate S. Extracellular Vesicles for Childhood Cancer Liquid Biopsy. Cancers Vol.16 No.9 (2024). doi:10.3390/cancers16091681 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98361
Title
Extracellular Vesicles for Childhood Cancer Liquid Biopsy
Corresponding Author(s)
Other Contributor(s)
Abstract
Liquid biopsy involves the utilization of minimally invasive or noninvasive techniques to detect biomarkers in biofluids for disease diagnosis, monitoring, or guiding treatments. This approach is promising for the early diagnosis of childhood cancer, especially for brain tumors, where tissue biopsies are more challenging and cause late detection. Extracellular vesicles offer several characteristics that make them ideal resources for childhood cancer liquid biopsy. Extracellular vesicles are nanosized particles, primarily secreted by all cell types into body fluids such as blood and urine, and contain molecular cargos, i.e., lipids, proteins, and nucleic acids of original cells. Notably, the lipid bilayer-enclosed structure of extracellular vesicles protects their cargos from enzymatic degradation in the extracellular milieu. Proteins and nucleic acids of extracellular vesicles represent genetic alterations and molecular profiles of childhood cancer, thus serving as promising resources for precision medicine in cancer diagnosis, treatment monitoring, and prognosis prediction. This review evaluates the recent progress of extracellular vesicles as a liquid biopsy platform for various types of childhood cancer, discusses the mechanistic roles of molecular cargos in carcinogenesis and metastasis, and provides perspectives on extracellular vesicle-guided therapeutic intervention. Extracellular vesicle-based liquid biopsy for childhood cancer may ultimately contribute to improving patient outcomes.