Publication: Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats
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Issued Date
1986-01-01
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ISSN
03784274
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2-s2.0-0022623439
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Mahidol University
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SCOPUS
Bibliographic Citation
Toxicology Letters. Vol.30, No.2 (1986), 151-157
Suggested Citation
Chaivat Toskulkao, Thirayudh Glinsukon Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats. Toxicology Letters. Vol.30, No.2 (1986), 151-157. doi:10.1016/0378-4274(86)90097-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9869
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Title
Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats
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Abstract
The binding of [ 3 H]aflatoxin B 1 (AFB 1 ) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of afb 1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB 1 metabolism by hepatic microsomes from ethanol-treated rats to aflatoxins m 1 (AFM 1 ) and Q 1 (AFQ 1 ) was increased when compared to those of control microsomes. These results suggest that an increase in AFB 1 binding to liver nucleic acids and AFB 1 metabolism after pretreatment of ethanol resulted from an increase in hepatic mixed-function oxidases and a possible decrease in hepatic glutathione (GSH) content which subsequently lead to an increase in hepatotoxicity of AFB 1 . © 1986.