Mechanisms of renal failure after unilateral ureteral obstruction in rats
2
Issued Date
2024
Copyright Date
1989
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xi, 117 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Physiology))--Mahidol University, 1989
Suggested Citation
Somchai Pondeenana Mechanisms of renal failure after unilateral ureteral obstruction in rats. Thesis (M.Sc. (Physiology))--Mahidol University, 1989. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99985
Title
Mechanisms of renal failure after unilateral ureteral obstruction in rats
Alternative Title(s)
กลไกการล้มเหลวของไตภายหลังการอุดตันของท่อปัสสาวะในหนู
Author(s)
Abstract
Renal blood flow (RBF) and glomerular filtration rate (GFR) were significantly decreased after released of 24 hours of unilateral ureteral obstruction (UUO) in rats. The mechanisms responsible for these reduction are still unclear. The present studies were performed to investigate the role of prostaglandin and thromboxane on the reduction of glomerular filtration rate, especially after renal blood flow was normalized by iso-oncotic volume loading. Furthermore, the effect of calcium blocker, verapamil on renal function after UUO was also investigated. Inhibition of thromboxane synthesis by imidazole did not improve the depressed RBF or GFR after UUO, but with simultaneous iso-oncotic loading RBF was normalized whereas GFR was only 50% of control. With prostaglandin inhibition by indomethacin, GFR was slightly elevated in the absence of any change in RBF. Simultaneous iso-oncotic loading in this group resulted in normalization of both RBF and GFR. Interestingly, verapamil infusion resulted in both improvement of GFR and RBF about 110% and 42% of pretreatment values, respectively. Furthermore, iso-oncotic loading in this group also normalized both RBF and GFR. These results suggest that thromboxane may not have any effect on renal function or hemodynamic after UUO, whereas, indomethacin induced a marginal increase in GFR possibly via an increment in Kf and /or an elevation in glomerular proximal hydrostatic pressure. Lastly, both vasodilation and an increment in Kf may contribute to the elevation of both GFR and RPF, induced by verapamil.
Description
Physiology (Mahidol University 1989)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Physiology
Degree Grantor(s)
Mahidol University