Publication:
Intestinal epithelium brush border and microsome chemistry. I. Crude cholera toxin effects

Issued Date

1972-01-01

Resource Type

Article

ISSN

10960945
00144800

DOI

10.1016/0014-4800(72)90068-8

Other identifier(s)

2-s2.0-0015418552

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Experimental and Molecular Pathology. Vol.17, No.2 (1972), 187-197

Suggested Citation

Gordon J. Leitch Intestinal epithelium brush border and microsome chemistry. I. Crude cholera toxin effects. Experimental and Molecular Pathology. Vol.17, No.2 (1972), 187-197. doi:10.1016/0014-4800(72)90068-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10003

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Title

Intestinal epithelium brush border and microsome chemistry. I. Crude cholera toxin effects

Author(s)

Gordon J. Leitch

Other Contributor(s)

Mahidol University

Abstract

Sucrase, trehalase and aryl amidase are most probably located on the luminal surface of the intestinal microvilli, while sialic acids are found in glycoproteins in the glycocalyx and elsewhere on the cell surface. Phospholipids, cholesterol and glycolipids probably constitute the plasma membrane core. Exposure of the intestinal lumen surface to crude cholera toxin resulted in significant reductions in brush border and microsome sialic acids, phospholipids and cholesterol: protein ratios and brush border glycolipids: protein ratios. Cholera toxin had only minor effects on the three brush border enzymes. The toxin neuraminidase activity was insufficient to account for the observed effects on membrane sialic acids. © 1972.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/10003

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Scopus 1969-1990